Blood serum proteins

Boocock G, Popplewell DS. 1966. In vitro distribution of americium in human blood serum proteins. Nature 210 1283-1284. 

Popplewell DS, Boocock G. 1967. Distribution of some actinides in blood serum proteins. In Kombeig HA, Norwood WD, eds. Diagnosis and treatment of deposited radionuclides. Amsterdam Excerpta Medica Foundation, 45-55. 

It is known that part of this process involves the 80-kDa blood serum protein transferrin that tightly binds and transports two ferric iron ions. Because the iron binding uses only 30% of transferrin s metal binding capacity, it has long been thought to bind and transfer other metal ions (including perhaps chromium) in vivo, although this has not been demonstrated by experiment. 

Figure 3.20 Pesticide in rat blood serum on vinyl alcohol polymer column. Conditions column, Asahipak GS320 (vinyl alcohol copolymer gel), 50 cm x 7.6 mm i.d. eluent, 0.05 M phosphate buffer containing 0.2 M sodium chloride pH 7.2 in 20% aqueous methanol flow rate, 1.0 ml min-1 detection, UV 254 nm. Peaks 1, blood serum protein and 2, methomyl.

Peter E, Lehmann M. 1981. Interaction of thorium with blood serum proteins in vivo. Int J Radiat Biol Relat Stud Phys Chem 40 445-450. 

Losytska V, Naida I, Tsiganov V (1997) Toxin-binding abihty of blood serum proteins in burned patients with the use of Enterosgel. In Biosorption methods and preparations in prophylactic and therapeutic practice, Eirst Conference, Kyiv (In Ukrainian), pp 121-122... 

An Illustration of the Electrophoretic Pattern of Blood Serum Proteins... 

A copper-binding protein, ceruloplasmin, which is a blood serum protein, has been demonstrated in milk by immunodiffusion techniques (Hanson et al. 1967 Poulik and Weiss 1975). It may be the enzyme ferroxidase (EC 1.16.3.1). 

Steklenev, E. P. and Marinchuk, G. E. 1981. Interspecies polymorphism of blood serum proteins in some representatives of a bovine subfamily (Bovinae) and their hybrids. TeitoL Genet. 75(2), 67-73 (Russian). 

Golovko (Kulikova), N.I. (1964). Electrophoretic study of blood serum proteins in Black Sea large and small horse-mackerel (In Russian). Trudy Azovsko-cher-nomorskogo Nauchno-issledovatelskogo Instituta Morskogo Rybnogo Khozyaistva I Okeanografii 22,73-94. 

Ipatov, V.V. (1970). Dynamics of blood serum proteins in Baltic cod in relation to reproductive products, maturation and season (In Russian). Voprosy Ikhtiologii 10, 892-896. 

Transferrins exist in blood sera, milks and avian egg whites in the relatively high concentrations of 0.1% to 16% of the solids. The highest concentrations have been found in avian egg whites (28) and, in general, the concentrations in avian egg whites are higher than in the other fluids. In fact, the lowest concentration reported in avian egg whites is approximately equal to the concentrations usually found in vertebrate blood sera, namely 2—3% of the solids. Milk, however, has much lower concentrations, and values as low as 0.1% (20 mg isolated from 1 liter of milk) have been indicated (62). Small amounts of transferrins also have been reported in other fluids, such as cerebrospinal fluid (29, 105), seminal fluid (87) and urine (15). Interpretations of the significance of these observations, however, should await further and more detailed studies because the presence of blood serum proteins in small quantities in other body fluids may be adventitious. Transferrin was not found in chemically detectible amounts in the egg white of the desert tortoise (37). But since no other reports apparently have been made on eggs of other reptiles or fish, the presence or absence of transferrins in these materials must be considered as yet uninvestigated. 

The effects of conditioning layers of two important blood serum proteins, albumin and fibrinogen were investigated. Protein adsorption was studied using bovine serum albumin (BSA) and fibrinogen (F) from Sigma. The samples were incubated for 3 h at 37°C in solutions of albumin (1 mg/mL) and fibrinogen (0.2 mg/mL) prepared in phosphate buffered saline (PBS, 0.01 M phosphate buffer, 0.0027 M KC1, 0.137 MNaCl, pH 7.4). After the incubation period, the samples were rinsed 3 times with PBS and analyzed by the various surface characterization techniques. 

The proportion of a Tc bone agent which is taken up by bone after intravenous injection will be affected by its binding to proteins in the blood serum. The proportions of the plasma Tc which were protein bound two hours after administration were found to be 16, 31, 54 and 85% with HEDP, MDP, PYP and tripolyphosphate respectively. In addition, the proportion of the administered dose of Tc which was taken up in bone was found to increase linearly with the fraction of Tc in the plasma which was not protein bound. Cox has reported a linear decrease in bone uptake with molecular weight for this series of bone agents, an observation which appears to reflect differences in their plasma protein binding behaviour. Thus the blood serum proteins may compete with bone for the Tc complexes and reduce the bone labelling efficiency of the radiopharmaceutical. The "Tc-diphosphonate formulations showed better performance in this respect than "Tc-PYP or Tc-tripolyphosphate. 

K4. Karpyuk, S. A., Determination of the blood serum protein fractions by a rapid method. Lab. Delo 8, 33-36 (1962). 

Anomalous Depression of the Freezing Temperature by Blood-Serum Proteins of Fishes... 

Clinically, ethymidine exerts a beneficial influence on lung cancer, cancer of the ovaries and the lymph nodes of the neck [512,555,556]. Its side effects include nausea, vomiting, impaired hearing and haemopoiesis [512]. Change in blood serum protein fractions was noted during chemotherapy in patients with ovarian cancer [557]. 

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