Targeted techniques

It is interesting to note, however, that at higher energies heavy ions can produce comparable yields to protons and at much lower specific energy. The main reason is that thick-target techniques now become feasible for heavy ions as well. The consequence is that, microampere-for-microampere at 50 MeV/u, ZC projectiles should be the equivalent of 600 MeV protons for isotope production, and are possibly better for the most exotic products [HARM]. 

Similarly, topical targeting techniques (including advanced aerosol systems and dermal or transdermal formulations) have been introduced or are about to be introduced that provide prolonged localized delivery or alternative means of systemic delivery. Both pose problems of a different kind (and perhaps magnitude), depending on whether the lungs or the skin, respectively, are the site of action or the portal of entry for systemic delivery. 

T. K. Sawyer in P. Veerapandian, Ed., Stmc-ture-Based Drug Design Diseases, Targets, Techniques and Developments, Marcel Dek-ker. New York, 1997, pp. 559-634. 

We have briefly reviewed polymer assemblies from block copolymers, their biodistribution, and the targeting technique that guides them to a specific site in the body. In this section, we will describe the practical efforts that have been made in the field of recent DDS using polymer assemblies. 

Another example of a potential receptor relay for leukocyte migration is the N-formylpeptide receptors. By using gene-targeting techniques, Hartt et al. (107) demonstrated that A-formylpeptides can induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two Af-formyl-peptide receptors FPR and FPR2. 

Ng DKS, Foo DCY, Tan RR, El-Halwagi MM. Automated targeting techniques for concentration-and property-based total resource conservation networks. Comp Chem Eng 2010 34(5) 825—45. 

Proactive and reactive recovery techniques such as the ones here described, but also many others, can be implemented in critical systems. However, it would be highly interesting to assess their actual convenience for a given system before to carry out them physically. Thereby, we think that the models developed in previous section can be useful for this purpose and with this thought in mind, we show in this section how a software design can offer interfaces through which eventually it will be combined, at UML level, with the FT target techniques. The example tries to be a blueprint about how to ... 

Targeted techniques. A promising avenue of approach is the manipulation of plant gene expression by antisense RNA (Bird and Ray,... 

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