Liposomes active targeting

In addition to the passive targeting of tumors due to the EPR effect, active targeting of PEGylated liposomes has also been successful. A study by Huwyler and coworkers (1996), for example, showed that coupling a monoclonal antibody to the surface of PEGylated liposomes resulted in significant transfer of the liposomes across the blood-brain barrier, which is difficult to achieve otherwise. The attached... 

Active Targeting of Liposomes Based on Ligand-Receptor Interactions... 

Duffels, A., Green, L.G., Ley, S.V. and Miller, A.D. (2000) Synthesis of high-mannose type neoglycolipids Active targeting of liposomes to macrophages in gene therapy. Chem. Eur. J., 6,1416-1430. 

Meers, P. Enzyme-activated targeting of liposomes. Adv. Drug Deliv. Rev. 53(3) 265-272. 2001. 

Maruyama, K., Ishida, 0., Takizawa, T., and Moribe, K. Possibility of active targeting to tumor tissues with liposomes. Adv. Drug Del. Rev. 40 89-102, 1999. 

A company selects liposomes as targeted delivery system because of their ability to exploit the EPR phenomenon for targeted delivery of its active compound. What is the preferred size range of the liposomes to be produced ... 

Active targeting is used to describe the specific liposomal drug localization achieved by grafting various moieties (antibodies, lectins, polymers, etc.) on the carrier surface. 

Although all the active targeting liposomes mentioned earlier have not left the laboratory, nonspecific sterically stabilized liposomes are being tested in clinical trials. Doxorubicin is the anticancer agent which is used as standard therapy, and it has the most serious side effects (mucositis, cardiotoxicity), so its incorporation in liposomes and bioavailability enhancement are under scrutiny [386-388]. 

Systemic administration of drugs in the form of nanoparticulates intravenously has been widely studied. Currently, there are some liposomal anticancer and antifungal medications in clinical use. These products show relative increase in drug bioavailability in the target sites. They are not, however, active targeting systems with recognition ligands on the surface. 

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