Injection tablets

For assaying oxytetracycline content in injections, tablets, capsules, ointments, and oral suspensions, the United States Pharmacopoeia 28 [1] uses a liquid chromatography method described in the assay under oxytetracycline. For oxytetracycline and Nystatin capsules and for oral suspension, United States Pharmacopoeia 28 [1] uses a microbiological method listed under antibiotics-microbial assays <81>. 

The most commonly used opiate substitute is methadone which has been available since the Second World War. It is a potent analgesic with a long half life, and thus once substituted for diamorphine can be reduced over a variable period of time. It is available in ampoules (for injection), tablets, linctus (2 mg in 5 ml), and mixture (1 mg in 1 ml). The use of ampoules and tablets is to be discouraged and many centres now are using the methadone mixture. This can be prescribed by any medical practitioner and requires no central licence. The use of ampoules and tablets has led to abuse, and these preparations have more of a black market value than the mixture. The amount of mixture used will depend on the amount of street heroin consumed and its potency, but it is usual to start at a safe dosage of between 30 and 50 mg daily for opiate dependents consuming half to one gramme... 

Hydromorphone is available through injections, tablets, oral solution, and suppositories. The usual route of administration is by way of swallowing tablets. For patients who have difficulty swallowing tablets, a flavored oral solution is available. This liquid form of the drug can be poured into a medicine dropper for measurement by the patient or a nurse. The liquid can also be added to soft foods to make it easier for the patient to ingest. Some of these liquid formulations may contain alcohol. 

The analyst should be aware of certain less common preparations which may be encountered. Homoeopathic Preparations. These are usually round, flat/flat tablets witii rough surfaces, 5 to 6 mm in diameter, and contain mainly lactose. Injection Tablets. Small, totally soluble tablets used for making solutions for injection. The most commonly encountered until recently were diamor-phine tablets. These were round, flat/flat tablets, 4 mm in diameter and 2 mm tiiick, weighing 30 mg. They have been discontinued but they may still be seen, having been burgled from pharmacies. These tablets should not be confused with LSD microdots which are usually highly coloured. 

Included in the FDA Inactive Ingredients Guide (capsules inhalations IM, IV, and SC injections tablets, oral solutions, and syrups). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. 

Ivermectin Mites, ticks, fleas Parenteral solution (s.c. injection) tablet (p.o.)... 

Formulations of xanthines include intravenous injection, tablets and capsules. Examples of xanthine bronchodilators are theophylline and aminophylline. 

Treatments for hypogonadism in the form of testosterone injections, tablets, skin patches, and skin gels are available. Some men use these devices in an attempt to revive masculine traits that begin to decline normally as one grows older. Many individuals believe, like Brown-Sequard, that testosterone can be something of a miracle drug that will restore their lost youth. It has at times been recommended also as a treatment for a host of medical problems, including infertility, impotence, lack of sex drive, osteoporosis,... 

Opioids formulated in crush-resistant, water-insoluble tablets may provide a lower risk for diversion, adulteration, and abuse (snorting, injecting). Tablets containing mixtures of an agonist plus an antagonist that is released if the tablet is adulterated are also being studied. 

The iodimetric method of assay is favoured for many official purposes and it can be applied, with very little sample preparation, to injections, tablets and solution-tablets. For ointments and similar preparations it is not directly applicable since high results may be obtained due to iodine absorption by the base. For preparations of this type Boymond has recommended iodimetric determination after mixture with benzene and extraction with water. 

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