Tablet slugs

Most capsules are filled on piston-tamp machines. These are fully automatic fillers in which pistons or tamping pins lightly compress the individual doses of powders into plugs (sometimes referred to as slugs ) and eject the plugs into the empty capsule bodies. The compression forces are low, often in the range of 50 200 N, or about 50-100-fold less than typical tablet compression forces. Hence, the plugs frequently will have the consistency of very soft compacts and will not be able to be recovered intact from the filled capsule. 

In the third country, roller compaction was substituted for the slugging process. While the sizing of the slugs and compacts were completed on different machines, and the particle size results were not exactly the same in each situation, the tablet content uniformity results were equivalent. Content uniformity relative standard deviations of 1.5-2.0% ( = 10 tablets) were routinely achieved. The tablet dissolution profiles averaged 95% or higher within 30 minutes in each country. 

Powders compressed into flat-faced tablets by action of punch and die, comminuted and screened to form feed for final compression. Dry granulation, slugging, pre-compression Heavy duty tableting press... 

In the pharmaceutical industry large, often poorly-formed, tablets or slugs are made from fine cohesive powders in large capacity tablet presses and then comminuted to form a granular feed suitable for final tableting [10]. Slugs are typically 1 or 2 in. (2.5 or 5.1 cm) in diameter and perhaps in. (1.3 cm) thick. Results comparable to those accomplished with this piston and die method are also obtained by roll compaction followed by granulation (see Section 2.2). 

Non-medicinal Preparations. These include a variety of preparations such as sweetener tablets, fertiliser tablets, stink bombs, indoor fireworks, and slug pellets. 

Compression aids to help form a good compact, whether on dry granulation (slugging) prior to tableting or on tablet compression. Most are derived from plant, animal, or mineral origin (microcrystalline cellulose, lactose, or magnesium carbonate). 

Traditionally, tablets have been made by granulation, a process that imparts two primary requisites to formulations compactibility and fluidity. Both wet granulation and dry granulation (slugging or roll compaction) are used (Table 1). Regardless of whether tablets are made by direct compression or granulation. 

There are three methods of tablet manufacture designed to confer these essential attributes to a tablet formulation. Wet granulation and direct compression are the most important, with dry granulation (also known as precompression or slugging) used in some circumstances. Fig. 1 shows the processes of wet granulation and direct compression broken down into their constituent stages. 

The density of granules used in tablet production is influenced by the densification of the slugs or compacted ribbon (7-9). To determine the porosity and pore size distribution of a ribbon or granules, mercury intrusion porosimetry may be used. This technique can also be used to evaluate the homogeneity of density/pressure distribution on a compact or granule which in turn affects the characteristics of the final granulation. In addition, gas... 

Khan KA, Musikabhumma P. Effect of slugging pressure on the properties of granules and tablets prepared from potassium phenethicillin. J Pharm Pharmacol 1981 33 627. 

Many pharmaceutical companies employ tabletting presses for the production of large slugs to use the still-available old presses which were replaced by modern high speed machines. In this application, large amounts of dust are... 

Hydrophilic matrix tablets are manufactured using traditional tablet manufacturing methods of direct compression (DC), wet granulation or dry granulation (roller compaction or slugging) depending on formulation properties or on manufacturer s... 

Punch-and-die press for the production of large tablettes or slugs which are crushed to obtain granulate. Mostly in the pharmaceutical industry. (See also tabletting machine.)... 

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