Tablet films

Rowe RC, Woolgar CG. Neurofuzzy logic in tablet film coating formulation. Pharmaceut Sci Technol Today 1999 2 495-7. 

Rowe RC, Roberts RJ. Simulation of crack propagation in tablet film coatings containing pigments. Int J Pharm 1992 78 49-57. 

M.C. Madamba, W.M. Mullett, S. Debnath and E. Kwong, Characterization of tablet film coatings using a laser-induced breakdown spectroscopic technique, AAPS PharmSciTech, 8 (4) Article 103 (http //www. aapspharmscitech.org/) (2007). 

Tablets, film-coated 382 mg carbenicillin (118 mg indanyl sodium ester) Rx)...

Most active principles and pharmaceutical forms are processed in the presence of organic solvents or reagents. The current regulations on products generally restrict to a few p.p.m. the amount of residual solvent. This very low concentration level could favour the CO2 utilization when non-polar compounds have to be eliminated. On the other hand, the elimination of residual solvents from tablets, films or other pharmaceutical preparations in which organic solvent are involved has been addressed [15]. Another application is related to the removal of residues from medical materials such as monomers, additives or polymerization residues from polymers or elastomers. Purification of active principles includes elimination of other undesired molecules pesticides from some vegetal extracts, and antibacterials suspected of toxic co-extracts from natural sources. 

Appearance The tablets should be examined for such problems as tablet mottling, picking of the monogram, tablet filming, and capping of the tablets. If the tablets are colored, the color quality needs to be examined. 

The PVA-PEG graft copolymer Kollicoat IR is the new instant-release, aqueous coating polymer from BASF. Due to its low viscosity and excellent mechanical properties, it permits solid content of up to 30% and leads to fine and smooth tablet film coatings. 

Prater, D., Wilde, J., and Meakin, B. (1980), A model system for the production of aqueous tablet film coating for laboratory evaluation,/. Pharm. Pharmacol., 32(Suppl.), 90. 

Wilson, K., and Crossman, E. (1997), The influence of tablet shape and pan speed on intra-tablet film coating uniformity, Drug Dev. Ind. Pharm., 23,1239-1243. 

Plumb, A. P., Rowe, R. C., York, P., and Doherty, C. (2003), Effect of varying optimization parameters on optimization by guided evolutionary simulated anneahng (GESA) using a tablet film coat as an example formulation, Eur. J. Pharma. Sci., 18, 259-266. 

Rowe RC. Quantitative opacity measurements on tablet film coatings containing titanium dioxide. Int J Pharmaceut 1984 22 17-23. 

Rowe RC. The opacity of tablet film coatings. J Pharm Pharmacol 1984 36 569-572. Rowe RC. The measurement of the opacity of tablet film coatings in-situ. Acta Pharm Suec 1984 21 201-204. 

Work on expert systems in the specific domain of tablet film coating was initiated in April 1990, using a rule induction tool in order to develop a system for the identification and solution of defects in film-coated tablets. Although not strictly a formulation expert system, the developed system did contain knowledge whereby a given formulation known to cause defects could be modified to provide a solution. The completed system described by Rowe and Upjohn. 

Fig. 11 Structure of the expert system developed by Rowe et for the formulation of tablet film coatings.

Rowe, R.C. Knowledge representation in the prediction of the opacity of tablet film coatings containing titanium dioxide. Eur. J. Pharm. Biopharm. 1995, 41, 215-218. Rowe, R.C. Predicting film thickness on film coated tablets. Int. J. Pharm. 1996, 133, 253-256. 

Rowe, R.C. Roberts, R.J. The effect of some formulation variables on crack propagation in pigmented tablet film coatings using computer simulation. Int. J. Pharm. 1992, 86, 49-58. 

Sakellariou, P. Rowe, R.C. White, E.T.F. The solubility parameters of some cellulose derivatives and polyethylene glycols used in tablet film coating. Int. J.Pharm. 1986, 57, 175-177. 

Included in the FDA Inactive Ingredients Guide (oral, tablets, film-coatings IV injections). Included in parenteral products licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. 

Rowe RC. The opacity of tablet film coatings. ] Pharm Pharmacol 1984 36 569-572. 

Although it is used in lotions, the marked degreasing properties of isopropyl alcohol may limit its usefulness in preparations used repeatedly. Isopropyl alcohol is also used as a solvent both for tablet film-coating and for tablet granulation, where the isopropyl alcohol is subsequently removed by evaporation. It has also been shown to significantly increase the skin permeability of nimesulide from carbomer 934. ... 

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