Tablet coating methods

Properties of lakes that enhance their usefiilness iaclude their opacity, their abiUty to be iacorporated iato products ia the dry state, their relative iasolubihty, and their superior stabiUty toward heat and light. Such properties have made possible the more effective and more efficient preparation of candy and tablet coatings, and often eliminate the need to remove moisture from dry products before coloring them. Lakes have also made possible the coloring of certain products that, because of their nature, method of preparation, or method of storage, caimot be colored with ordinary color additives. 

Otilonium bromide Powder and tablet Non-destructive quantitation method for QC of three production steps (blend, cores and coated tablets). Validated method following ICH guidelines. Relative errors lower than 1 % 147... 

For hydroxypropyl methylcellulose acetate succinate, a novel enteric dry coating method has been developed [31]. The unique feature of this method is that the enteric polymer is added in powder form (e.g., mixed with talcum directly to tablets or pellets) whereas a plasticizer diluted with paraffin is sprayed separately. The tablet core temperature is around 40°C, and the film is cured for a short time. To achieve a homogenous film, the rates of powder feeding and plasticizer spray have to be adjusted such that the two processes start and end simultaneously. 

Drug formulations are designed to provide an attractive, stable, and convenient method to use products. Conventional dosage forms may be broadly characterized in order of decreasing dissolution rate as solutions, solid solutions, suspensions, capsules and tablets, coated capsules and tablets, and controlled release formulations. 

Lieberman, H. Lachman, L. Particle-coating methods. In Pharmaceutical Dosage Forms Tablets Marcel Dekker, Inc. New York, 1982 Vol. 3, 120-144. 

The potential of this method to monitor film coating was investigated in the second experiment. Tablets coated with 2 to 7% ethylcellulose were used to predict film coat thickness. Near-IR spectral changes correlated well with film thickness. Using the first PC, a SEE of0.0002 in. was obtained for coating thicknesses ranging from 0.001 and 0.003 in. Drennen and... 

We now examine the example of the formulation of a delayed release tablet by the dry-coating method. 

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