Otilonium bromide

C7H7NO2 I50-I3-0) see Bentiromide Methotrexate Nafamostat Otilonium bromide Tetracaine... 

CftH 5NO 100-37-8) see Adiphenine Benactyzine Bielamiverine Dicycloverine Otilonium bromide Oxybuprocaine Oxyphenonium bromide Parethoxycaine Procaine Valethamate bromide 2-(diethylamino)ethanol hydrochloride (C HijCINO 14426-20-1) see Chloroprocaine... 

Eurlanetto, S., Orlandini, S., Massolini, G., Faucci, M. T., La Porta, E., and Pinzauti, S. (2001). Optimisation and validation of a capillary electrophoresis method for the simultaneous determination of diazepam and otilonium bromide. Analyst 126(10), 1700-1706. 

Otilonium bromide Powder and tablet Non-destructive quantitation method for QC of three production steps (blend, cores and coated tablets). Validated method following ICH guidelines. Relative errors lower than 1 % 147... 

Otilonium bromide Powder and tablet PLS Non-destructive quantitation method. Errors less than 0.8% 131... 

A fiber optic probe was used by Blanco et al. for analysis of spasmoctyl samples with the active compound otilonium bromide and cellulose, maize starch, sodium starch glycolate, and glyceryl palmitostearate as excipients. Another study from this group covered the identification, qualification of the substance, and the quantification of the active component. A library search with a comparison to the near-infrared spectra of 163 pharmaceuticals was involved. An on-line monitoring for the determination of the endpoint of polymorph conversions in pharmaceutical processes was recently described further investigations into this field were published and are noted previously. ... 

Otilonium bromide [ban, inn] is a quaternary ammonium compound, a MUSCARINIC CHOLINOCEPTOR ANTAGONIST which can be used as a visceral antispasmodic. Otrivine-Antistin" antazoline. 

Clidinium bromide, another quaternary ammonium compound with antimuscarinic activity, is used in a fixed combination with chlordiazepoxide hydrochloride (2.5 mg of clidinium and 5 mg of chlordiazepoxide Librax) however, such combinations are of limited value in patients with IBS because of the risk of habituation and rebound withdrawal. Cimetropium is another antimuscarinic compound that reportedly is effective in patients with IBS. Otilonium bromide has been used extensively for patients with IBS in other parts of the world. It is an ammonium salt with antimuscarinic effects that also appears to block Ca + channels and neurokinin NK-2 receptors. Mebeverine hydrochloride is a derivative of hydroxybenzamide that appears to have a direct effect on the smooth-muscle cell, blocking K+ and Ca channels. It is widely used outside of the United States as an antispasmodic agent for patients with IBS. 

Mannucci, C. Bertini, J. Cocchini, A. Perico, A. Salvagnini, F. TViolo, A. High-performance liquid chromatographic method for assay of otilonium bromide, diazepam, emd related compounds in finished pharmaceutical forms. J.Pharm.Sci., 1993, 82, 367-370... 

Susanne lindqvist JH, Sharp P, Johns N, et al. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M3 receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol. 2002 137 1134-1142. 

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