T-cell dependent antigen

In rodents, sheep red blood cells (SRBC) are routinely used for immunization. The antibody response is determined using the plaque forming cells assay (PFC) or by plasma SRBC-specific antibody titer [21, 22], As an alternative to SRBC, other T-cell-dependent antigen may be used, including keyhole limpet hemocyanin (KLH), tetanus toxoid (TT), or pneumococcal antigen. 

Mouse CCR5 Yes Normal Increased susceptibility to Listeria Increased susceptibility to LPS-induced endotoxemia Enhanced DTH reaction Increased humoral responses to T cell-dependent antigenic challenge... 

The use of sRBC as a T cell-dependent antigen has been shown to be useful in assessing drug- and chemical-induced immunosuppression (Luster et al.,... 

Significant decrease in secondary antibody response to T cell-dependent antigen... 

Significant decrease in NK activity significant decreases in ex vivo prohferative responses to ConA and LPS significant decreases in primary and secondary antibody responses to T cell-dependent antigens... 

Significant decreases in ex vivo proliferative responses to ConA and LPS significant decreases in primary and secondary antibody response to T cell-dependent antigens Significant decrease in absolute number of peripheral blood T cells (CD3, CD4, and CDS) and B cells and in percentage of CD3 T lymphocytes (associated with decrease in CD4 valnes) in spleen and (CD4 and CDS valnes) in axillary lymph node Decreases in IgM and IgG antibody response to KLH Dose-related decrease in splenic and mesenteric lymph node T cells and CD4 T cells... 

In assays to assess the immunomodulatory activity of a polysaccharide isolated from white mulberry root bark, the compound was found to enhance proliferation of splenic lymphocytes in a synergistic manner in the presence of mitogens. However, the compound suppressed primary IgM antibody production from B cells, which was activated with lipopolysaccharide, a polyclonal activator, or immunized with a T-cell-dependent antigen, sheep red blood cells (Kim et al. 2000). 

CD40L Development of humoral responses to T-cell-dependent antigens M3 Chemokine binding and suhsequent Mocking fiom cellular receptors... 

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