Systems biology holistic approach

L. Munck, A new holistic exploratory approach to systems biology by near infrared spectroscopy evaluated by chemometrics and data inspection, J. Chemom., 21, 406 26 (2007). 

Chemical interference reflecting the holistic approach to complex processes proceeding in chemical and biological systems, but not to their components as is commonly practiced, characterizes the phenomenon, which real sense justifies the introduction of a new term. 

EPA and many states are now moving toward a watershed or basin management approach to water management. This is a holistic approach that looks at the multiple stresses and activities that affect a basin and evaluates these effects in the context of the survival of ecological systems. Biological criteria are recognized by states as a necessary... 

Chemical genomics represents a holistic approach since in principle the small molecules could interact with the whole proteome either through direct binding interaction or indirectly as a downstream effect through the signaling network. Since the cell response is the overall consequence of the interactions initiated by the small molecules, chemical genomics is closely associated with systems biology and network theory (Yildirim et al., 2007). 

Theodoridis, G., Gilka, H. G., and Wilson, I. D. 2011. Mass spectrometry-based holistic analytical approaches for metabolite profiling in systems biology studies. Mass Spectrom. Rev. 30 884-906. 

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