Synthetic enhancers

Leonard G (1993) Synthetic enhancement in gene interaction a genetic tool come of age. Trends Genet 9 362-366... 

PEA and tryptamine, the first examples of physiological enhancer substances, represent just the peak of an iceberg. The development of a tryptamine-derived synthetic enhancer substance that increased the performance of cul-... 

Tcf-1 and Lef-1 are not classical transcription factors in that they are incapable of activating transcription of reporter gene constructs from a synthetic enhancer containing multimerized Tcf/Lef binding sites. Lef-1 acts as... 

Keywords Bacterial enhancers Biological computation Gene regulatory networks Synthetic enhancer... 

Engineering Gene Circuits with Synthetic Enhancers... 

Synthetic Enhancers as a Basic Research Tool for a Biological Rosetta Stone Algorithm... 

Amit R (2012) TetR anti-cooperative and cooperative interactions in synthetic enhancers. J Comp Biol 19 115-125... 

The large rate enhancements observed for bimolecular nucleophilic substitutions m polai aprotic solvents are used to advantage m synthetic applications An example can be seen m the preparation of alkyl cyanides (mtiiles) by the reaction of sodium cyanide with alkyl halides... 

Apphcations of ultrasound to electrochemistry have also seen substantial recent progress. Beneficial effects of ultrasound on electroplating and on organic synthetic apphcations of organic electrochemistry (71) have been known for quite some time. More recent studies have focused on the underlying physical theory of enhanced mass transport near electrode surfaces (72,73). Another important appHcation for sonoelectrochemistry has been developed by J. Reisse and co-workers for the electroreductive synthesis of submicrometer powders of transition metals (74). 

Lubricants, Fuels, and Petroleum. The adipate and azelate diesters of through alcohols, as weU as those of tridecyl alcohol, are used as synthetic lubricants, hydrauHc fluids, and brake fluids. Phosphate esters are utilized as industrial and aviation functional fluids and to a smaH extent as additives in other lubricants. A number of alcohols, particularly the Cg materials, are employed to produce zinc dialkyldithiophosphates as lubricant antiwear additives. A smaH amount is used to make viscosity index improvers for lubricating oils. 2-Ethylhexyl nitrate [24247-96-7] serves as a cetane improver for diesel fuels and hexanol is used as an additive to fuel oil or other fuels (57). Various enhanced oil recovery processes utilize formulations containing hexanol or heptanol to displace oil from underground reservoirs (58) the alcohols and derivatives are also used as defoamers in oil production. 

Sulfonylureas. The hypoglycemic effect of sulfonylureas was first noted in the early 1940s when several patients died in hypoglycemic coma after testing glyprothia2ole, a synthetic sulfonamide used to treat typhoid. Chemical modifications which enhanced activity and lowered toxicity led to the development of the first-generation sulfonylureas. Carbutamide [339-43-5] the first commercial sulfonylurea, came onto the European... 

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