Synthetic biodegradable polymers, tissue

Nerem R.M., Braddon L.G., Scliktar D., Ziegler T., Tissue engineering and the vascular system in Attala A., Mooney D.J., Vacanti J.P., Langer R. (eds) Synthetic Biodegradable Polymer Scaffolds, Birkhauser, Boston, 1997, 165— 185. 

Hubbell, J. A. (1998) Synthetic biodegradable polymers for tissue engineering and drug delivery. Current Opinion in Solid State and Materials Science, 3, 246-51. 

Tissue Engineermg Using Synthetic Biodegradable Polymers... 

In our laboratory, we use synthetic biodegradable polymers as templates to which cells adhere and are transplanted. The polymers act as a scaffolding which can be engineered to allow for implantation of transplanted cells within only a few cell layers from the capillaries, and thus allow for nutrition and gas exchange by diffusion until successful engraftment is achieved. In this manner, we hoped to generate permanent functional new tissues composed of donor cells and recipient interstitium and blood vessels. 

Figure 2. Photograph of tissue engineered cartilage grown from synthetic biodegradable polymer mesh seeded with chondrocytes and then implanted for 7 weeks in a nude mouse.

P.X. (2012) Functionalized synthetic biodegradable polymer scaffolds for tissue engineering. Macromol. Biosci. Rev., 12 (7), 911-919. 

Synthetic biodegradable polymers have attracted much interest for short-term medical applications like sutures, dmg delivery devices, orthopedic hxaticni devices, wound dressings, temporary vascular grafts, stents, different types of tissue... 

A. Asti, L. Gioglio, Natural and synthetic biodegradable polymers different scaffolds for cell expansion and tissue formation, Int. J. Artif Organs 37 (3) (2014) 187—205. 

Linear Aliphatic Polyesters. Linear ahphatic polyesters are the most frequently used synthetic biodegradable polymers in tissue engineering and many other biomedical applications (26-28). These polymers degrade through hydrolysis of the ester bonds in the polymer backbone. The degradation rates and profiles differ between these polymers owing to their compositional, structural, and molecular weight differences. 

Saxena, A.K., Marler, J., Benvenuto, M., Willital, G.H., Vacanti, J.P., 1999. Skeletal muscle tissue engineering using isolated myoblasts on synthetic biodegradable polymers preliminary studies. Tissue Eng. 5, 525—532. 

No.l3, 2003,p.2287-93 NEW SYNTHETIC BIODEGRADABLE POLYMERS AS BMP CARRIERS FOR BONE TISSUE ENGINEERING... 

Synthetic Biodegradable Polymers-Based Nanoflbers for Tissue Engineering... 

Table 1.16 Physical Properties of Synthetic Biodegradable Polymers Used as Scaffolds in Tissue Engineering (Morita and Ikada, 2002, with permission from Marcel Dekker)... 

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