SYNTHESIS reagents for

P. Wipf, Handbook of Reagents for Organic Synthesis Reagents for High Throughput Solid-Phase and Solution-Phase Organic Synthesis, Wiley, Chichester, 2005. 

Use Base for production of methylene blue, photodeveloper, reagent for detection of hydrogen sulfide, reagent for cellulose, organic synthesis, reagent for certain bacteria. 

Use Catalyst for organic synthesis, reagent for alkaloids, additive to plating processes, as precipitant and inorganic ion exchanger, minerals separation, mordant. 

Use Dyes, organic synthesis, reagent for lignin, nitrite, chloroglucinol. 

Use Organic synthesis, reagent for detection of albumin, medicine, pharmacy, herbicides. 

Miller, M.M. and Boger, D.S. (2005) Polystyrene-1-ethyl-3-(3 -dimethylaminopropanej-carbodiimide Hydrochloride (PS-EDCI), in Handbook of Reagents for Organic Synthesis, Reagents for Glycoside, Nucleotide and Peptide Synthesis (ed. D. Crich), John Wiley Sons Ltd, Chichester, pp. 529-33. 

Precaution Extremely flamm. sol ns. (> 20%) will ignite spontaneously in air ignites on contact with water or CO2 may cause potentially explosive polymerization of styrene NFPA Health 3, Flammability 4, Reactivity 2 Uses Solution polymerization initiator for polyolefin elastomers polymerization catalyst for food-contact polybutadiene for repeated use lithiation reagent Grignard-type reagent intermediate in prep, of lithium hydroxide org. synthesis reagent for metallation of org. compds. rocket fuel components to generate tetrahydrofurans from (tributylstannyl) methyl ethers... 

Uses Chemical intermediate coupling agent in peptide synthesis reagent for amide formation and esterification pharmaceutical injectables Regulatory FDA approved for injectables (IM, IV) Manuf./Distiib. Aldrich http //www.sigma-aldrich.com, Fluka http //www.sigma-aldrich.com, Schweizerhall http //www.susinc.com. Sigma... 

Storage Store refrigerated keep tightly closed Uses Synthesis reagent for mercapto functional group modification Manuf./Distrib. Acros Org. http //www.acros.be] Aldrich http //www.sigma-aldrich.com] Alfa Aesar http //www.alfa.com] Am. Radiolabeled Chems. http //www.arc-inc.com] Fluka http //www.sigma-aldrich. com ICN Biomed. Research Prods. http //www.icnbiomed.com] Isotec http //www.isotec.com] J.T. Baker http //www.jtbaker.com] Lancaster Synthesis Pfaltz Bauer http //www.pfaltzandbauer.com... 

Uses Copromoter for cobalt-contg. polyester-accelerator systems solvent for cellulose ethers extractant ingred. of solvent mixts. for cellulose esters synthesis of nifedipine (a cardiac drug) org. synthesis reagent for Dane salt formation intermediate for vitamins, feed additives, pharmaceuticals, pesticides component for flavors and fragrances solvent for fragrances in cosmetics prod, of azo dyes Manuf./Distrib. Aceto http //www.aceto.com,... 

Storage Hygroscopic light-sensitive store 15-25 C in cool, dry place keep tightly closed Uses Phase transfer catalyst synthesis reagent for nickel- and palladium-catalyzed cross-coupling reactions iodination reagent Manuf./Distrib. Amyl http //www.amyl.com-. Contract Chems. Ltd http //www.contract-chemicals.com... 

Handbook of reagents for organic synthesis reagents for heteroarene functionahzation / edited by Andre B. Charette, Universite de Montreal, Montreal, QC, Canada, pages cm Includes indexes. 

The development and application of selective C-H functionalization processes toward heteroarene synthesis is rapidly evolving. In 2006, the first Handbook of Reagents for Organic Synthesis, Reagents for Direct Functionalization of C-H Bonds... 

Forms a complex with H2O2 which functions as a peracid in synthesis. Reagent for gc anal, of amino acids and for the F nmr anal, of alcohols and phenols. Gas. Fp -129°. Bp -26°. pK 6.58 (hydrate). 

L.F. Fieser and M. Fieser, "Reagents for Organic Synthesis" (Vol. I, p, 911) John Wiley and Sons, New York, London, Sydney (1967). 

L.F. Fieser, Reagents for Organic Synthesis, Vol 1, Wiley, N.Y., 1967 or standard textbooks. 

The /-butoxycarbonyl group (Boc, "t-box ) has been eMens vely used in peptide synthesis, and Boc derivatives of many amino acids are commercially available. The customary reagent for the preparation from the amine is t-butyl azidoformate in water, dioxane/water, DMSO, or DMF. The cleavage by acids of medium strength proceeds with concomitant loss of isobutene and carbon dioxide (L.A. Carpino, 1957, 1973 see section 4.1.2.2). 

Before describing how p keto esters are used as reagents for organic synthesis we need to see how these compounds themselves are prepared The mam method for the prepa ration of p keto esters is the Claisen condensation... 

Biomotrifluoioethylene is a valuable reagent for the synthesis of trifluorovinyhc compounds by means of its intermediate organometaUic compounds. 

L. F. Fieser andM. Fieser, Reagents for Ofganic Synthesis, Vol. 3,John Wiley Sons, Inc., New York, 1972, p. 147. 

Alkylchloro- and alkylbromoboranes are valuable reagents for the synthesis of di- and trialkylboranes having different alkyl groups. Thexylchloroborane [75050-54-5], ThxBHCl (16) is a very useful reagent. 

Nitrates. Iron(II) nitrate hexahydrate [14013-86-6], Fe(N03)2 6H20, is a green crystalline material prepared by dissolving iron in cold nitric acid that has a specific gravity of less than 1.034 g/cm. Use of denser, more concentrated acid leads to oxidation to iron(III). An alternative method of preparation is the reaction of iron(II) sulfate and barium or lead nitrate. The compound is very soluble in water. Crystallisation at temperatures below — 12°C affords an nonahydrate. Iron(II) nitrate is a useful reagent for the synthesis of other iron-containing compounds and is used as a catalyst for reduction reactions. 

Triethylphosphonoacetic acid [867-13-0] (PEPA) is a useful olefination reagent for Homer-Emmons reactions in organic synthesis. 

Synthesis of Peptide. There is continual progress ia the improvement of instmments and reagents for peptide synthesis, especially "soHd phase polymerization" (90) (see Proteins). This method is suitable for the synthesis of peptides with 20 30 amino acid units. 

Radioactive tracers account for about 20% of the worldwide market for consumables and reagents for life science research. In 1994 the value was estimated at about 300 million. The principal fuU line manufacturers are Du Pont—NEN Research Products (Boston, Massachusetts) and Amersham International (Amersham, U.K.). These companies share roughly equaHy about 85% of the radiochemicals worldwide market. In addition to an extensive line of catalog products, these suppHers offer custom labeling and custom synthesis services. The rest of the market is shared by producers of a limited range of products or services, such as ICN Biomedicals (Costa Mesa, California) and American Radiolabeled Chemicals (St. Louis, Missouri). 

Unsymmetrical functional tetraorganotins are generally prepared by tin hydride addition (hydrostaimation) to functional unsaturated organic compounds (88) (see Hydroboration). The realization that organotin hydrides readily add to atiphatic carbon—carbon double and triple bonds forming tin—carbon bonds led to a synthetic method which does not rely on reactive organometatiic reagents for tin—carbon bond formation and, thus, allows the synthesis of... 

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