Cardiac drugs

De Ponti F, Poluzzi E, Montanaro N (2000) QT-interval prolongation by non-cardiac drugs lessons to be learned from recent experience. Em J Clin Pharmacol 56 1-18... 

A clinical pharmacist has recommended that the dose of a cardiac drug be reduced from 0.25 mg to 0.2 mg in a renally impaired patient. In both the normal and renally impaired patient, the dosing interval was... 

In problem number 7, if it is decided to use the same dose of 0.25 mg of the cardiac drug in the renally impaired patient, what should be the dosing interval ... 

TRICYCLIC ANTIDEPRESSANTS 11 AVERMECTINS 12 CARDIAC DRUGS 13 IBUPROFEN 14 CHL0R0-, NITRO-PHENOLS 15 TESTOSTERONE STEROIDS... 

Probe 12. cardiac drugs Probe 13. ibuprofen Probe 14. chlorophenols nitrophenols... 

In attempts to prepare methylated xanthine analogues with greater therapeutic effectiveness as diuretic and cardiac drugs than theophylline (LXIV) and theobromine (LXV), it was found that some of the intermediate 6-aminouracils (LXVI) showed considerable activity as oral diuretics in experimental animals... 

As noted earlier, lithium is contraindicated in patients with unstable congestive heart failure or the sick sinus node syndrome ( 307, 328). In older patients or those with prior cardiac histories, a pretreatment ECG should be obtained. Except for the potential adverse interactions with diuretics, the concomitant use of other cardiac drugs is generally safe. Because verapamil may lower serum levels of lithium, however, more careful monitoring may be required to assure continued therapeutic effects (329). Some data also indicate that verapamil may predispose to lithium neurotoxicity. Conversely, increased lithium levels leading to toxicity has occurred with methyidopa and enalapril. When antihypertensive therapy is necessary, b-blockers are a reasonable choice when lithium is coadministered. 

Cardiac drugs Higher doses of digoxin required in hyperthyroidism lower doses in hypothyroidism... 

French researcher C. A. Natvelle purifies a substance he called digitalin from the foxglove leaf. This purified substance ultimately led to the formulation of the conventional cardiac drugs digoxin and digi-toxin. 

The 1800s saw the transformation of many herbal remedies into conventional drugs. The story about how one herb, foxglove (Digitalis purpurea), was transformed into the modern-day cardiac drug digoxin, provides a good example. 

DSC has also been used to determine partition coefficients between phospholipids and water, avoiding radiolabeled solutes and high concentrations. One example is the partitioning of cardiac drugs into DMPC liposomes [48] (Table 3.9). The drug concentration in the liposomes was calculated using the following equation ... 

Tab. 3.9 Partition coefficients of cardiac drugs measured by DSC. (Reprinted from Tab. 1 of ref. 48, with permission from Elsevier Science)...

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