Synergistic utilization

Even as the computational prediction error rate is reduced to acceptable levels, many cases will be encountered in which the predictions are indistinguishable to within error. In a scenario in which several different in silico designs are given equivalent but favorable activity predictions, the end user s medicinal experience may help decide which to promote to synthesis. The quality of that decision at this point will be strongly influenced by how easy it is to understand the different contributions to the computational predictions. Interpretability is thus critical for synergistically utilizing the experience of the end user. 

The OPTIMELT TCR process takes advantage of the high H2O and CO2 concentrations ( 85% total) in the flue gas of oxy-fuel combustion and synergistically utilizes them as reactants for the endothermic reforming reactions. By comparison, the combined H2O and CO2 concentration of the air combustion flue gas is only about 30% of the flue gas and the remaining 70% N2 cannot participate in the endothermic reactions. 

Adhesives. High concentration (>10%) solutions of poly(ethylene oxide) exhibit wet tack properties that are used in several adhesive appHcations. The tackiness disappears when the polymer dries and this property can be successfully utilized in appHcations that require adhesion only in moist conditions. PEO is also known to form solution complexes with several phenoHc and phenoxy resins. Solution blends of PEO and phenoxy resins are known to exhibit synergistic effects, leading to high adhesion strength on aluminum surfaces. Adhesive formulations are available from the manufacturers. 

Barnard and colleagues119 reported a powerful absorption band at 1040 cm"1 for sulphoxides, where absorption was proportional to concentration. Oba120 utilized this wavelength for a rapid determination of the synergistic insecticide Sulfox-Cide , 1,2-... 

Quality is everyone s job. The laboratory personnel must have a constrac-tive role in all laboratory functions and processes. They must operate with a team spirit and enhance the synergistic effect of teamwork. All laboratory members are links in the chain and nodes in the quality grid. Their strengths and abilities must be fully and effectively utilized. Within this... 

Synergistic Use of Mixed Separation Mechanisms. In OC the first SBC utilizes conventional separation by molecular size exclusion. 

Another approach to the management of IM resistance is to combine agents that are individually active against CML but have differing mechanisms of action that may allow either additive or synergistic effects in a non-cross-resistant marmer. This approach has been extensively studied in the literature and will not be reviewed in detail here. An excellent discussion of combination therapy is foimd in the reviews by Hochhaus and La Rosee (52,85). Some combination approaches have utilized famesyl transferase inhibition such as lonafamib in combination with IM, inhibitors of the mammalian target of rapamycin (mTOR) in combination with IM and combining mycophenolic acid, an inhibitor of the JAK-STAT pathway. 

The lack of significant impact of CPEs on transdermal delivery vehicles is related to the inherent nonspecific activity of CPEs in the different strata of the skin, as discussed earlier. This limitation may be overcome by utilization of mixtures of CPEs. Research has already shown that binary mixtures of CPEs provide increased permeation enhancement as well as increased safety compared to single enhancers. Such unique chemical combinations, called synergistic combinations of penetration enhancers or SCOPE formulations, offer new opportunities in transdermal drug delivery (46). 

Phenolic antioxidants together in combination with thiodiprop-ionate compounds as synergists have been used for this purpose, e.g., n-octadecyl-3-(4 -hydroxy-3, 5 -di-ferf-butylphenyl)propionate and dilauryl thiodipropionate (14). These systems have a tendency to develop colored impurities as a byproduct of their antioxidant function. The production of colored impurities becomes particularly evident in spray drying processes that utilize partially inert atmospheres (12). 

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