Suture biocompatible

Cellular response, suture material biocompatibility and, 24 216 Cellulases, 5 361-362 70 282-284 benefits of, 70 283 as bleaching agents, 4 64 cotton modification, 8 30 textile industry, 70 302 Cellulon, 5 363-364... 

Biocompatibility is an important consideration. Again, many unintended consequences are often found, unfortunately after the fact. In the areas of synthetic hip and knee replacement, use of alloys is often called for, yet some patients are found to have long-term allergies to certain metals present in minute amounts that eventually require replacement of the joint material. Thus, extensive testing is required before a new suture becomes commercially available. 

Williams et al. (2) prepared biocompatible poly-co-hydroxyalkanoates, (I), containing long and short alkyl pendants that were used as sutures, rivets, tacks, staples, and screws in humans. 

Early development of polymers in injectable drug delivery primarily involved PLA and poly(lactic-co-glycolic) acid (PLGA) due to the prior use of these polymers in biomedical applications as sutures. Besides the safe and biocompatible nature of these polymers, their ease of availability made them ideal first candidates for screening parenteral CR formulations. Some of the early biodegradable polymer-based products for injectable sustained release used these polymers. However because... 

Leading candidates from the Sects. 3.2-3.5 will be selected and will be evaluated in an orderly form to characterize their properties followed by application to animals for the evaluation of biocompatibility and effectiveness for closing wounds without sutures. 

This test is an alternative for studying the reaction of tissue to a device for a period of days to weeks. In this test, a tissue pocket is made in the skin above the muscle layer, the device is inserted into the pocket, and the pocket is sutured or stapled closed. Normally the device is placed deep into the pocket away from the site of insertion of the device so that reactions at the suture or clip site do not affect the evaluation of biocompatibility. 

Hu W, Huang ZM (2010) Biocompatibility of braided poly(L-lactic acid) nanofiber wires applied as tissue sutures. Polym Int 59(1 ) 92—99... 

Biodegradable materials were initially used in medical applications such as sutures, prostheses, controlled drug-release systems, and vascular grafts. These applications are enabled by their biocompatibility, their ability to be absorbed by the body, and because of their mechanical properties appropriate for such applications [6]. 

Because the lactic acid polymers are biocompatible, they have already been applied to medical practice. For instance, some sutures are made from lactic acid plastics. 

Poly (e-caprolactone), poly lactides, and polyglycolides have quite unusual properties of biodegradability and biocompatibility. The majority of polymers used in the biomedical field to develop implants, sutures, and controlled drug-delivery systems are the aforesaid resorbable polyesters produced by ring-opening polymerization of cyclic (di)esters. 

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