Suppository bases polyethylene glycol

Suppositories Sodium bicarbonate and potassium bitartrate in a water soluble polyethylene glycol base otc)... 

In the formulations presented here, mixtures of the polyethylene glycols, Lutrol E 400, Macrogol 1500, Macro-gol 4000, and Macrogol 6000, are intended as water-soluble base for suppositories and ovula. 

Nakajima, T., et al. 1990. Indomethacin sustained-release suppositories containing sugar ester in polyethylene glycol base. Chem Pharm Bull 38 1680. 

Suppositories Theobroma oil, glycinerated gelatin, or polyethylene glycol base plus medicinal agent Insertion into body cavity... 

Suppositories are solid dosage forms intended for insertion in body cavities like rectum, vagina, and occasionally in the urethra for local or systemic effects. The length, shape, and weight of these depend on the body cavity it is used for. These melt, soften, or dissolve after application depending on the type of suppository base applied. Cocoa butter base suppositories usually melt in contact with the body temperature. Other bases, such as polyethylene glycol, glycerin. 

The base used in the formulation of suppositories can often affect the rate of decomposition of the active ingredients. Aspirin decomposes in several polyoxyethylene glycols which are often incorporated into suppository bases. Degradation was shown to be due in part to transesterification, giving the decomposition products salicylic acid and acetylated polyethylene glycol. The rate of decomposition, which followed pseudo first-order kinetics, was considerably greater than when a fatty base such as cocoa butter was used. Analysis of commercial batches of 100 mg indometacin-polyethylene glycol... 

Polyethylene glycols are widely used in food, cosmetics, and topical pharmaceuticals (e.g., ointments and suppository base). 

The rectal suppository is available in a concentration of 5 mg of oxymorphone hydrochloride in a base consisting of polyethylene glycol 1000 and polyethylene glycol 3350. 

The suppositories contain sulfanilamide 15.0% in a water-miscible, nonstaining base made from lactose, propylene glycol, stearic acid, diglycol stearate, methylparaben, propylparaben, trolamine, and water, buffered with lactic acid to an acid pH of approximately 4.3. Each suppository contains sulfanilamide 1.05 g with lactose in a base made from polyethylene glycol 400, polysorbate 80, polyethylene... 

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