SUPERPRO DESIGNER

In this section, a pilot-scale process that has been developed specifically for the production and purification of AdVs for gene therapy [80] is analyzed and evaluated for large-scale manufacturing with the use of the process simulator software SuperPro Designer (Intelligen, Inc., Scotch Plains, NJ). The major objective of the... 

TABLE 10.1-4. Summary of Input Data Used in the Bioprocess Simulator SuperPro Designer... 

SUPERPRO DESIGNER 4.9 (includes BatchPro, EnviroPro, and BioPro Designer)... 

Six major process simulators are widely used in the chemical process industries today. These are ASPEN PLUS, BATCH PLUS and HYSYS.Plant (Aspen Technology, Inc.), PRO/n (Simulation Sciences, Inc.), CHEMCAD (ChemStations, Inc.), and SUPERPRO DESIGNER (Intelligen, Inc.). In this book and the associated multimedia CD-ROM, coverage is provided of ASPEN PLUS and HYSYS.Plant, which are the two most widely used process simulators. It should be mentioned that once the principles of process simulation are understood, it is a relatively easy matter to switch from one simulator to another. 

In recent years, property information systems have become widely available in computer packages. Some are available on a stand-alone basis, such as PPDS2 (1997), while others are available within the chemical process simulators, such as ASPEN PLUS, HYSYS.Plant, PRO/n, CHEMCAD, BATCH PLUS, and SUPERPRO DESIGNER. Commonly, constants and parameters are stored for a few thousand chemical species, with programs provided to estimate the property values of mixtures, and determine the constants and parameters for species that are not in the data bank using estimation methods or the regression of experimental data. Virtually all of the property systems estimate the properties of mixtures of organic chemicals in the vapor and liquid phases. Methods are also provided for electrolytes and some solids, but these are less predictive and less accurate. 

As in the steady-state simulation of continuous processes, it is convenient to convert from a process flowsheet to a simulation flowsheet. To accomplish this, it is helpful to be familiar with the library of models (or procedures) and operations provided by the simulator. For example, when using SUPERPRO DESIGNER to simulate two fermentation reactors in series, the process flowsheet in Figure 4.25a is replaced by the simulation flowsheet in Figure 4.25b. In BATCH PLUS, however, this conversion is accomplished without drawing the simulation flowsheet, since the latter is generated automatically on the basis of the recipe specifications for each equipment item. 

More specifically, a list of the BATCH PLUS equipment models is provided in Table 4.2a. These are organized under the class of model, with a list of type of equipment, and an indication of whether a model can be used in batch, continuous, or either mode. Similarly, for SUPERPRO DESIGNER, a list of procedures (equipment models) is provided in Table 4.2c. These are organized here as groups of equipment types. 

When a SUPERPRO DESIGNER flowsheet is defined to be in continuous mode, streams are reported on a per hour basis. Scheduling information is not required, and no overall batch time is calculated. Individual batch processes can be inserted into the flowsheet, with their batch and turnaround times specified. 

With SUPERPRO DESIGNER and BATCH PLUS, caution must be exercised when introducing continuous operations into batch processes, as no warnings are provided when a continuous process unit is running dry. When a feed to a continuous unit runs dry, the simulator assumes that this unit is shut down and restarted when the feed returns. Clearly, sueh operation is infeasible for many units, such as distillation colunms and chemical reactors. Consequently, when continuous processes are included, it is important to check the results computed by the batch simulators to be sure that unreasonable assumptions have not been made. 

Have completed several exercises involving steady-state simulation using one of the four simulators, ASPEN PLUS, HYSYS.Plant, CHEMCAD, and PRO/II, and involv-ing batch process simulation using one of the two simulators, BATCH PLUS and SUPERPRO DESIGNER. 

Process simulators, steady state, dynamic, and batch, are used throughout the textbook (ASPEN PLUS, HYSYS.Plant, CHEMCAD, PRO/II, BATCH PLUS, and SUPERPRO DESIGNER). This permits access to large physical property, equipment, and cost databases... 

The process simulation market underwent severe transformations in the 1985-1995 decade. Relatively few systems have survived they are CHEMCAD, Aspen Plus, Aspen HYSYS , PRO/II, ProSimPlus, SuperPro Designer, and gPROMS. Nowadays,... 

Using the SuperPro designer, select pure component and then select n-hexane. At 7 = 25°C and pressure = 1 atm, the density of pure n-hexane is determined using the following equation obtained from the pure component property... 

Verify hand calculation results with Hysys, PRO/II, Aspen, and SuperPro Designer. 

Hysys, SuperPro Designer, and Aspen Plus results are exactly the same. There is discrepancy between hand calculations and the result obtained with SuperPro mainly due to physical properties such as specific heat. 

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