Superparamagnetic iron nanoparticles SPIONs

Frederic T., Carsten E., and Anne M.H. Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung. Eur. J. Pharm. Biopharm. 86(1) (2014) 98-104. 

M.M. Lin, et al.. Development of superparamagnetic iron oxide nanoparticles (SPIONS) for translation to clinical applications, IEEE Trans. Nanobiosci. 7 (4) (2008) 298-305. 

In the past two decades, iron oxide or superparamagnetic iron oxide nanoparticles (SPION, e.g., y-Fe Oj, FejO and associated compounds) have been actively studied for medical image, drug dehvery, and hyperthermia treatment purposes. SPION has... 

Taylor EN, Kummer KM, Durmus NG, Leuba K, Tarquinio KM, Webster TJ. Superparamagnetic iron oxide nanoparticles (SPION) for the treatment of antibiotic-resistant biofihns. Small 2012 8 3016-27. 

Composite materials are of interest due to the potential synergistic properties that may arise from the combination of two or more precursors. Two such precursors are wood or cellulose fibers and magnetic nanoparticles. These hybrid materials exhibit the inherent properties of the fiber substrate, in particular flexibility and strength, and also the magnetic properties of the surface bonded nanoparticles. Superparamagnetic Iron Oxide Nanoparticles (SPION) covered with a polymer have been used in medical research such as devices for cell isolation, immobilization of enzymes, controlled releasesystems and separation of biological... 

Mahmoudi M, Sant S, Wang B, Laurent S, Sen T (2011) Superparamagnetic iron oxide nanoparticles (SPIONs) development, surface modification and applications in chemotherapy. Adv Drug Deliv Rev 63 24-46... 

Recently, Reddy et al. demonstrated that labeling of mesenchymal stem cells (MSCs) with superparamagnetic iron oxide nanoparticles (SPlONs) coated with chitosan did not alter the proliferation, surface marker expression or differentiation capacity of MSCs [92]. For comparison, Resovist, a commercially available MR contrast agent coated with carboxydextran, showed alteration to the chondrogenesis capacity of MSC. In addition, the chitosan-coated SPION-loaded MSCs did not show any toxic effects in viability studies over a 3-week period. Further, in vivo MR imaging of the chitosan-coated SPION-loaded MSCs injected into the brain of an ischemic brain rabbit model enabled the tracking of the stem cells for up to 2 weeks (Fig. 2). 

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