Superparamagnetic nanoparticles

Stevens, P.D., Li, G.F., Fan, J.D., Yen, M. and Gao, Y. (2005) Recycling of homogeneous Pd catalysts using superparamagnetic nanoparticles as novel soluble supports for Suzuki, Heck, and Sonogashira cross-coupling reactions. Chemical Communications (35), 4435-4437. 

NeubergerT, Schopf B, Hofmann H, Hofmann M, von Rechenberg B (2005) Superparamagnetic nanoparticles for biomedical applications possibilities and limitations of a new drug delivery system. Journal of Magnetism and Magnetic Materials 293 483 196. 

A) Elaboration of PLLA-based superparamagnetic nanoparticles Characterization, magnetic behavior study and in vitro relaxivity evaluation Abstract. Oleic acid-coated magnetite has been encapsulated in biocompatible magnetic nanoparticles (MNP) by a simple emulsion evaporation method. 

Zhang H, Lee MY, Hogg MG et al (2010) Gene delivery in three-dimensional cell cultures by superparamagnetic nanoparticles. ACS Nano 4 4733 743... 

Chouly, C., D. Pouliquen, et al. (1996). Development of superparamagnetic nanoparticles for MRI effect of particle size, charge and surface nature on biodistribution. J Microencapsul 13(3) 245-55. 

Neuberger, T., et al. (2005), Superparamagnetic nanoparticles for biomedical applications Possibihties and limitations of a new drug dehvery system, J. Magnet. Magnetic Mater., 293(1), 483-496. 

Superparamagnetic nanoparticles can form chains even at zero field as has been demonstrated by simulations and by experiment in a dispersion of iron nanoparticles at zero field. Ring formation happens by unpaired dipoles at the ends of chains and have also been observed with 27 nm cobalt particles. External magnetic fields can by applied in order to orient flexible chains in one direction enabling formation of superstructures. 

FluidMag-HS is an aqueous based magnetic fluid containing superparamagnetic nanoparticles having a core size of 10 nm and hydrodynamic diameter of about 60 nm. 

One strategy that has been adopted to enhance the possibility of surface contact has been through the use of superparamagnetic nanoparticles (117) and a 0.5-T magnet placed close to the flow chamber. 

Darton NJ, Hallmark B, Huan X, et al. The in-flow capture of superparamagnetic nanoparticles for targeted therapeutics. Nanomedicine 2008 4 19-29. 

Kim, D.K., Zhang, Y., Kehr, J., Klason, T., Bjelke, B.andMuhammed,M. (2001) Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain. /. Magn. Magn. Mater., 225, 256-261. 

D. K. Kim, Y. Zhang, J. Kehr, T. Klason, B. Bjelke, and M. Muhanuned Characterization and MRl study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain Journal of Magnetism and Magnetic Materials 225, 256-261 (2001). 

Iron nanoparticles prepared by pyrolysis of poly(ferrocenylsilanes) inside periodic mesoporous sihca displayed the absence of room-temperature hysteresis in the magnetization curves which shows their superparamagnetic behavior [55]. However, magnetic properties cannot always be easily interpreted. For example, for this material data analysis of magnetization curves resulted in the ambiguous conclusion that either particle size distribution is bimodal, or iron particles have an oxide layer which behaves as small superparamagnetic nanoparticles. So magnetic measurements should be combined with other techniques (probably, in this case, EXAFS may be useful) to allow more accurate evaluation of particle structure. 

Thermotherapy using biocompatible superparamagnetic nanoparticles has been evaluated in a phase 1 trial patients with locally recurrent prostate cancer [50]. The magnetic fluid was injected transperineally into the prostates and hyperthermic to thermoablative temperatures were achieved in the prostates... 

Gupta Ajay, K. Wells, S. Surface-modified superparamagnetic nanoparticles for drug delivery Preparation, characterization, and cytotoxicity studies. IEEE Trans. Nanobiosci. 2004, 3 (1), 66-73. 

M RI contrast agents consist not only of superparamagnetic nanoparticles, but also of particular types of paramagnetic complexes. In general, MRI contrast agents are divided into two major types ... 

The size and shape of nanoparticles must be adjusted for the desired application since, on the nanometer scale, magnetic properties such as saturation magnetization and magnetic anisotropy strongly size- and shape-dependent. In particular, Ms is greatly decreased with decreasing size of a superparamagnetic nanoparticle. As Ms directly determines the rj relaxivity, size control for the crystalline core is the key requirement. 

Kohler, N., Sun, C., Wang, J., Zhang, M., 2005. Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells. Langmuir 19, 8858-8864. 

Kohler, N., Sun,C., et al. Methotrexate-Modified Superparamagnetic Nanoparticles and Their Intracellular Uptake into Human Cancer Cells. Langmuir,21(19), 8858-8864... 

Kim KS, Park J-K (2005) Magnetic force-based multiplexed immunoassay using superparamagnetic nanoparticles in microfluidic channel. Lab Chip 5 657-664... 

Figure 8.3 Typical morphology of nanocomposite comprised of poiy(vinyi pivalate)/Fe304 superparamagnetic nanoparticles formed through emuision poiymerization [11].

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