Polymeric microparticles preparation

Table 2 Polymeric Microparticles Prepared by Using RESS ...

Garay I., Pocheville A, Madariaga L. (2010). Polymeric microparticles prepared by supercritical antisolvent precipitation. Powder TechnoL, 197,211-217. 

Torchilin, V. P. (2006). Multifunctional nanocarriers. Advanced Drug Delivery Reviews, Vol. 58, 14, (December 2006), pp. (1532-1555), ISSN 0169-409X Tran, V. T., Benoit, J. P. Venier-Julienne, M. C. (2011). Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy International Journal of Pharmaceutics, Vol. 407,1-2, (December 2011), pp. (1-11), ISSN 0378-5173... 

The question whether the intramolecularly crosslinked microparticles of non-aqueous polymer dispersions are really microgels is also justified, considering non-aqueous dispersions prepared from acrylic copolymers and melamine/formaldehyde crosslinker with particle sizes of about 300 nm. [45, 343]. In any case, these crosslinked polymeric microparticles are useful constituents of high-solids coatings, imparting a yield stress to those solutions which probably involves attractive forces between the microparticles. 

The possibility of controlling the morphology of the product is relevant, especially in the forms of bio-polymer preparations and controlled delivery systems. Polymeric microparticles, fibers, or three-dimensional networks can be produced by tuning the operating variables. 

The above cited authors further modified the procedure (57) by applying ultrasonication during the whole polymerization time the resulting pure PMMA and composite particles are presented in Figure 8.10. Figure 8.10(a) represents PMMA microparticles prepared under mechanical stirring. As can be seen, the particles pose uniform size distribution, with a slightly smaller diameter ( 6 pm) than in the previous paper (48). The other two pictures present... 

Methods of preparing polymeric microparticles with tailored surface chemistries are of technological importance in a wide range of applications including drug delivery, biochemical diagnostics, and paint/coating products [34], Microparticle... 

In view of the availability of a wide variety of biocompatible and biodegradable polymers, and the ease of preparation of stable microparticles with predictable physicochemical characteristics, antibodies have been conjugated to polymeric microparticles for controlling their in vivo deposition. 

Kim K, Kim D (2005) High-performance liquid chromatography separation characteristics of molecular-imprinted poly(methacrylic acid) microparticles prepared by suspension polymerization. J Appl Polym Sci 96(1 ) 200—212... 

V.-T. Tran, J.-P. Benot, and M.C. Venier-Julienne. Why and how to prepare biodegradable, monodis-persed, polymeric microparticles in the field of pharmacy International Journal of Pharmaceutics, 407(12) 1-11, 2011. 

Both W/O/W and O/W/O emulsions have attracted considerable attention because of their potential applications in food science [4-7], cosmetics [8-10] and pharmaceutics [11]. In particular, there have been many studies on the pharmaceutical applications of W/O/W emulsions because the internal aqueous droplets can contain water-soluble drugs for controlled release or targetable delivery [12-14]. Solid microcapsules loaded vhth bioactive polymers are also prepared from W/O/W droplets by the solvent evaporation method [15-18]. Other applications studied thus far include the synthesis of shaped polymeric microparticles [19] and the use of the intermediating phase as the permeation membrane in separation technology [20-25]. 

Berg et al. reported the preparation and evaluation of microcapsules formed by the polymerization of methyl methacrylate in the presence of an oil-water macroemulsion. The oil phase was composed of an alkane (e.g., decane or hexade-cane), and the oil-water emulsions were stabilized by a variety of emulsifiers [42,43]. Both oil- and water-soluble initiators were used, and the monomer was introduced by either dissolving in the oil or feeding it through the water phase. The authors view this system to be an opportunity to study morphological characteristics of polymeric microparticles in the 1 to 100 im size range. 

STABILIZERS USED TO PREPARE POLYMERIC MICROPARTICLES BY EMULSIFICATION/ SOLVENT EVAPORATION METHOD Aminabhavi T Kulkarni V Kulkami A Karnatak University... 

Figure 7.6 SEM images of PS microparticles prepared by AIBN initiated dispersion polymerization of styrene in ethanol in the presence of PEHO-ClSImOTs as a stabilizer.

H. Huang, C. Chen, D. Zhang, J. Deng, Y. Wu, Helical substituted polyacetylene derived fluorescent microparticles prepared by precipitation polymerization. Macromol. Rapid Commun. 35, 908-915 (2014)... 

Spherical microparticles are more difficult to manufacture and can be prepared by several methods. One method prepares silica hydrogel beads by emulsification of a silica sol in an immiscible organic liquid [20,21,24,25]. To promote gelling a silica hydrosol, prepared as before, is dispersed into small droplets in a iater immiscible liquid and the temperature, pH, and/or electrolyte concentration adjusted to promote solidification. Over time the liquid droplets become increasingly viscous and solidify as a coherent assembly of particles in bead form. The hydrogel beads are then dehydrated to porous, spherical, silica beads. An alternative approach is based on the agglutination of a silica sol by coacervation [25-27], Urea and formaldehyde are polymerized at low pH in the presence of colloidal silica. Coacervatec liquid... 

Polymeric Materials. Photopolymer chemistry is also being used to prepare a variety of polymeric materials including crosslinked fibers and films (83), microporous gels, microporous polymers (84), microparticles (85) and battery electrodes (86) and components. 

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