Cefuroxime axetil

Cefuroxime axetil 30 mg/kg per day in 2 doses (max 1 g/day with suspension adult 250 mg twice daily) Nausea, vomiting, diarrhea, rash, diaper rash Suspension gritty and bitter tasting, not interchangeable with tablets (less bioavailable)... 

Cefdinir Cefpodoxime proxetil Cefuroxime axetil 600 mg/day in 1-2 doses 200 mg twice daily 250-500 mg twice daily 14 mg/kg per day in 1-2 doses 1 0 mg/kg per day in 2 doses 1 5-30 mg/kg per day in 2 doses Preferred oral liquid cephalosporin owing to palatability... 

Cefuroxime axetil 250 mg twice daily 20 mg/kg per day in 2 doses 10 days ... 

Second-generation cephalosporins—IV cefuroxime po cefaclor, cefditoren, cefprozil, cefuroxime axetil, and loracarbef. Third-generation cephalosporins—po cefdinir, cefixime, cefetamet, cefpodoxime proxetil, and ceftibuten. 

Cefuroxime axetil 20-30 rng/kg in two divided doses + metronidazole 30 mg/kg in three to four divided doses or clindamycin 10-30 mg/kg/day in three to four divided doses... 

Cefaclor 0.5 g orally every 8 hours4 or cefuroxime axetil 0.5 g orally every 12 hours ... 

Ruiz-Balaguer N, Nacher A, Casabo VG and Sanjuan MM (2002) Intestinal Transport of Cefuroxime Axetil in Rats Absorption and Hydrolysis Processes. Int J Pharm 234 pp 101-111. 

A few well-established prodrugs contain an (acyloxy)methyl or an [(alkoxycarbonyl)oxy]methyl group. Classical examples of the former are two prodrugs of /1-lactam antibiotics, namely pivampicillin (8.50), the (pivaloyloxy)methyl ester of ampicillin, and cefuroxime axetil (8.51), the... 

C. J. Campbell, L. J. Chantrell, R. Eastmond, Purification and Partial Characterization of Rat Intestinal Cefuroxime Axetil Esterase , Biochem. Pharmacol. 1987, 36, 2317 -2324. 

CEC provided repeatable separation of isradepin and its six by-products within 1.6 min on a 143 mm column packed with 3 pm Cig. CEC was found to be more selective compared to MEKC for the impurity profiling of pharmaceutical compounds such as fluticasone propionate and cefuroxime axetil. With a homemade column packed with 3 pm... 

Cefuroxime is a second-generation cephalosporin. Orally, cefuroxime is available as the prodrug, cefuroxime axetil. Cefuroxime is very well absorbed from the gastrointestinal tract and widely distributed in the body. 

This process has been operated successfully by Glaxo on a commercial scale for over 17 years. An important advance has been the development of an acid stable form of cefuroxime by esterification of the C4 ester group that has allowed the production of products suitable for oral administration. This new product Cefuroxime axetil (trade name Zinnat) has rapidly achieved market sales of ca. 300 in 1990-91... 

Cefaclor, cefuroxime axetil, cefprozil, and loracarbef can be given orally. The usual dosage for adults is 10-15 mg/kg/d in two to four divided doses children should be given 20-40 mg/kg/d up to a maximum of 1 g/d. Except for cefuroxime axetil, these drugs are not predictably active against penicillin-resistant pneumococci and should be used cautiously, if at all, to treat suspected or proved pneumococcal infections. Cefaclor is more susceptible to 13-lactamase hydrolysis compared with the other agents, and its usefulness is correspondingly diminished. 

Early Doxycycline, amoxicillin Cefuroxime axetil, penicillin... 

First-generation cephalosporins cefazolin for parenteral administration cefadroxil or cephalexin for oral administration. Second-generation cephalosporins cefuroxime for parenteral administration cefaclor, cefuroxime axetil, cefprozil, for oral administration. Third-generation cephalosporins ceftazidime, cefotaxime, ceftriaxone for parenteral administration cefixime, cefpodoxime, ceftibuten, cefdinir, cefditoren for oral administration. Fourth-generation cephalosporin cefepime for parenteral administration. Cephamycins cefoxitin and cefotetan for parenteral administration. 

Acute otitis media, sinusitis H influenzae, S pneumoniae, M catarrhalis Amoxicillin Amoxicillin-clavulanate, cefuroxime axetil, TMP-SMZ... 

CEFTIN for oral suspension, when reconstituted with water, provides the equivalent of 125 mg or 250 mg of cefuroxime (as cefuroxime axetil) per 5 mL of suspension. CEFTIN for oral suspension contains the inactive ingredients polyvinyl pyrrolidone K30, stearic acid, sucrose, and tutti-frutti flavoring. 

Cefuroxime is also a second-generation cephalosporin resistant to some -lactamases. It is used in veterinary medicine in intramammary treatments. Cefuroxime axetil is also a prodrug active by the oral route. It is absorbed from the gastrointestinal tract and its absorption is enhanced if the compound is given after... 

Robson, H., Craig, D.Q.M., and Deutsch, D. (2000) An investigation into the release of cefuroxime axetil from taste-masked stearic acid microspheres. II. The effects of buffer composition on drug rtelteafee. 

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