Sulphathiazole

CqHqNj02S2. Whitc powder, m.p. 200-203 C. Sulphathiazole has the typical actions of sulphonamides, being effective against y -haemolytic Streptococci, Pneumococci, Gonococci and Staphylococci. 

See sulphacetamide, sulphadiazine, sul-phadimidine, sulphaguanidine, sulphamera-zine, sulphamethoxypyridazine, sulphanilamide, sulphathiazole. 

In general, aromatic primary amino moiety (i.e., Ar-NH2), as present in a host of sulphadrugs viz., succinyl sulphathiazole, sulphamethoxazole, sulphaphenazole and other potent pharmaceutical substances, for instance sodium or calcium aminosalicylate, isocarboxazid, primaquine phosphate, procainamide hydrochloride, procaine hydrochloride and dapsone react with sodium nitrite in an acidic medium to yield the corresponding diazonium salts as expressed below ... 

Sulphadiazine Sulphathiazole Sulphamerazine Sulphamethazine Sulphamethoxazole Sulphadoxine Sulphaquinoxaline Sulphaphenazole Sulphasalazine 10-Desacetylbaccatine III Baccatine III Erythromycine... 

Titration with nitrous acid is used in pharmacopoeial assays of the following benzocaine, dapsone, primaquine, procainamide, procaine, sulphacetamide, sulphadoxine, sulphamethizole, sulphapyridine and sulphathiazole. 

Sulphonamides were supplied by Sigma (Sigma Chemical Company, St. Louis, MA 63178 USA) Sulphisomidine (SOMI), Sulphathiazole (THIA), Sulphamethizole (METH), Phtalylsulphacetamide (FTAL), Sulphacetamide (ACET), Sulphapyridazine (PYRI), Sulphamerazine (MERA), Sulphamethoxypyridazine (MEPY) and Sulphachloropyridazine (CLPY). 

Figure 7.10 represents the minimal selectivity plot after extraction of sulphisomidine, sulphathiazole, sulphamethizole and... 

Figure 7.8a The response surface of the selectivity Ojj of the extraction of sulphisomidine and sulphathiazole (selectivity plot)...

Antidiarrhoeal formulations containing phthalyl sulfathiazole or sulfaguanidine or succinyl sulphathiazole. 

Sulfanilamidothiazole Sulfathiazole Sulfatiazole Sulfonazolum Sulfothiazole Sulphathiazole Tiazin Thiazylsulfonamide... 

Figure 7.19 Ultraviolet trace (270 nm) obtained from SFC of a mixture of (A) sulphadoxine (1-SDX), (B) sulphamethazine (2-SMT), (C) sulpha-merazine (3-SMZ), (D) sulphadimethoxine (4-SDM), (E) sulphadiazine (5-SDZ), (F) sulphaquinoxaline (6-SQX), (G) sulphachlorpyridazine (7-SCP), and (H) sulphathiazole (8-STZ) on a 100 x 4.6-mm ID column packed with 5- tm amino-bonded Spherisorb. The mobile phase was initially carbon dioxide modified with 15% methanol at a flow rate of 4 ml/ min. After 4 min, the concentration of methanol was increased to 25%. Column pressure, 361 bars temperature, 90°C. [Reprinted from Ref. 33, J. Chromatogr. 540, 239 (1991) with kind permission of Elsevier Science Publishers, The Netherlands.]...

Many drugs can exist in more than one crystalline form, for example chloramphenicol palmitate, cortisone acetate, tetracyclines and sulphathiazole, depending on the conditions (temperature, solvent, time) under which crystallization occurs. This property is referred to as polymorphism and each crystalline form is known as a polymorph. At a given temperature and pressure only one of the crystalline forms is stable and the others are known as metastable forms. A metastable polymorph usually exhibits a greater aqueous solubility and dissolution rate, and thus greater absorption, than the stable polymorph. 

Disposition in the Body. Only about 5% of a dose is absorbed after oral administration and blood concentrations are therefore very low compared to other sulphonamides, usually less than 15 pg/ml. It is slowly hydrolysed to sulphathiazole in the gastrointestinal tract. 

Disposition in the Body. Readily absorbed after oral administration and acetylated in the body, about 20% of the sulphathiazole in the blood being in the form of the inactive A -acetyl derivative. It is rapidly excreted in the urine, about 60 to 90% of a dose being excreted in 24 hours about 20% of the excreted material is the acetyl derivative. 

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