Sulphathiazole sulphamerazine

Sulphadiazine Sulphathiazole Sulphamerazine Sulphamethazine Sulphamethoxazole Sulphadoxine Sulphaquinoxaline Sulphaphenazole Sulphasalazine 10-Desacetylbaccatine III Baccatine III Erythromycine... 

Sulphonamides were supplied by Sigma (Sigma Chemical Company, St. Louis, MA 63178 USA) Sulphisomidine (SOMI), Sulphathiazole (THIA), Sulphamethizole (METH), Phtalylsulphacetamide (FTAL), Sulphacetamide (ACET), Sulphapyridazine (PYRI), Sulphamerazine (MERA), Sulphamethoxypyridazine (MEPY) and Sulphachloropyridazine (CLPY). 

The 13C NMR chemical shifts of eight sulphonamide drugs (sulphanilamide, sulpha-guanidine, sulphathiazole, sulphasuxidine, sulphadiazine, sulphamerazine, sulphameth-iazine and sulphapyridine) have been determined and assigned93. 

It is perhaps relevant to note here that in clinical use sulphonamide mixtures are preferred to single drugs, to minimize the formation of crystal deposition in the kidney. The use of mixtures of related sulphonamides results in enhanced mutual solubility [284]. This is perhaps a case of hydrotropy. Lehr [285] has determined the solubility of a number of sulphonamide combinations, and Frisk et al. [286] have reported on the solubility of the combination sulphadiazine, sulphamerazine, and sulphathiazole. The influence of sulphanilamide on the solubility of sulphathiazole indicated that a 1 1 molecular complex was formed [287]. 

Tablets of Trisulphonamides J5.P.C. Although officially only the total sulphonamides are determined, Marzys has proposed a method for the determination of sulphadiazine, sulphamerazine and sulphathiazole in mixtures, using the thiobarbituric acid colorimetric method for sulphadiazine and an ultra-violet absorption method for the other two. The detailed method is as follows ...

Sulphamerazine and sulphathiazole Transfer a 5-ml aliquot of solution A to a 25-ml graduated flask and dilute to volume with 0-1N hydrochloric acid. Measure the extinctions at 243 m u (E 243 m/w) and 280 m (E 280 m ), using 1-cm cells with 0 1 N hydrochloric acid in the comparison cell. 

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