Succinyl-sulphathiazole

In general, aromatic primary amino moiety (i.e., Ar-NH2), as present in a host of sulphadrugs viz., succinyl sulphathiazole, sulphamethoxazole, sulphaphenazole and other potent pharmaceutical substances, for instance sodium or calcium aminosalicylate, isocarboxazid, primaquine phosphate, procainamide hydrochloride, procaine hydrochloride and dapsone react with sodium nitrite in an acidic medium to yield the corresponding diazonium salts as expressed below ... 

Antidiarrhoeal formulations containing phthalyl sulfathiazole or sulfaguanidine or succinyl sulphathiazole. 

Two derivatives of sulphathiazole, acylated on iV-4, have proved of great value in treating bacterial dysentery. These are the pro-drugs succinyl-sulphathiazole ( Sulfasuxidine ) and phthalysulphathiazole ( Sulfathali-dine , Thalazole ). The acyl-group is split off in the colon, from which very little sulphathiazole can be absorbed. 

---