Sulphathiazole sodium

Solution microcalorimetry is another thermal method for the determination of the difference in lattice energy of polymorphic solids. The difference in heat of solution of two polymorphs is also the difference in lattice energy (more precisely lattice enthalpy), provided of course, that both dissolution experiments are carried out in the same solvent (Guillory andErb 1985 Lindenbaum and McGraw 1985 Giron 1995). The actual value for A Hi is independent of the solvent, as demonstrated in Table 4.1 for the two polymorphs of sodium sulphathiazole. Note also that the calculated heats of transition are virtually identical in spite of the fact that the heat of solution (A//s) is endothermic in acetone and exothermic in dimethylformamide. 

Table 4.1 Heats of solution AHs (kcalmol ) measured at 25 °C and calculated heats of transition AHt for the two polymorphic forms of sodium sulphathiazole in two different solvents (adapted from Lindenbaum and McGraw 1985)...

In general, aromatic primary amino moiety (i.e., Ar-NH2), as present in a host of sulphadrugs viz., succinyl sulphathiazole, sulphamethoxazole, sulphaphenazole and other potent pharmaceutical substances, for instance sodium or calcium aminosalicylate, isocarboxazid, primaquine phosphate, procainamide hydrochloride, procaine hydrochloride and dapsone react with sodium nitrite in an acidic medium to yield the corresponding diazonium salts as expressed below ... 

Sulphanilylacetamide, 981 Sulphanilylurea, 995 Sulphaphenazole, 992 Sulphaphenylpyrazol, 992 Sulphapyridine, 992 (metabolite), 994 Sulphapyridine sodium, 993 Sulphapyridine, soluble, 993 Sulphaquinoxaline, 980 Sulphasalazine, 993 Sulphasomidine, 994 Sulphasomizole, xvii Sulphate conjugation, 291 Sulphathiazole, 995 (metabolite), 900, 978 Sulphathiazole sodium, 995 Sulphathiazole, soluble, 995 Sulphatriad, 979, 982, 995 Sulphaurea, 995 Sulphide, 68 Sulphinpyrazone, 996 Sulphinpyrazone sulphide, 996 Sulphinpyrazone sulphone, 996 Sulphonal, xvii Sulphonamides, colour test, 131 gas chromatography, 200... 

Fig. U Example of the bibliographic entries in the PDF for substances listed by compound name. Each name is followed by the formula and the d-spacings of the three strongest diffraction hnes, with the relative intensity as a subscript. The last column on the right is the card number in the PDF. Multiple entries with different principle lines are indications of polymorphic systems, for instance the three entries for sulphapyridine and sulphathiazole, the four entries for sulphanilamide and the two entries for sulphathiazole sodium hydrate, but additional bibliographic and crystallographic information should be obtained from the entries themselves.

Table 6.13 Solubility of sulphacetamide sodium and sulphathiazole sodium in liquid petrolatum and cottonseed oil bases...

Because of the limited solubility of the xanthine derivatives in water, their solubilization by hydrotropes has been the subject of much interest. Such diverse compounds as piperazine [279], sodium salicylate [280], adenosine [281], and diethanolamine [282] have been used to solubilize theophylline. The action of each is presumably due to complex formation. Neish [283] found that caffeine, a xanthine derivative, increased the solubility of a number of aromatic amines, including sulphapyridine, sulphathiazole, and certain dyes. 

Sulmarin, in D-00647 i> Sulphacetamide sodium, in A-OOlOO Sulphan blue, S-00058 l> Sulphathiazole, S-00059 l> Sulphental, see P-00064 Sulpyrin, see D-01100 Sumiacryl black G, see J-00001 Sumiacryl orange R, see A-00453 Sumiacryl red N6B, see A-00455 Sunchromine blue FBG, see E-00009 Superchrome garnet Y, see D-00693... 

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