Succinic acid dendrimers

Carnahan, M. A., and Grinstaff, M. W. 2001. Synthesis and characterization of poly(glycerol-succinic acid) dendrimers. Macromolecules, 34,7648-7655. 

Carnahan, M.A. Grinstaff, M.W. Synthesis and characterization of polyjglycerol-succinic acid) dendrimers. Macromolecules 2001, 34, 7648-7655. 

Glyco-coated dendrimers possess a core structure of varied chemical nature, with a number of peripheral groups to which carbohydrate moieties are attached. The most common core structures are based on polyaminoamides (PAMAM) or poly(propyleneimine) (Astramol ) with a primary amine at the periphery, and these are commercially available. Polyamides based on N,N-bis(3-aminopropyl)glycine and A,Ar-bis(3-aminopropyl)succinic acid have also been prepared.78... 

Recently, a polyamidoamine (PAMAM) dendrimer-succinic acid-PXT conjugate was prepared with a hydrolysable ester bond that is cleaved by esterasehydrolyzing enzyme [61]. The conjugate formulation showed 10-fold higher in vitro cytotoxicity than did the unconjugated drug. 

Amine-terminated, G3 (PAMAM) dendrimer, (0.316 g 45.7 moles) was dissolved in anhydrous methyl sulfoxide (5 ml) in a 100 ml round-bottom flask flushed with dry nitrogen. After dendrimer had completely dissolved, succinic anhydride (Aldrich) (0.363 g 3.6 mmol) was added to the reaction mixture with vigorous stirring, and the mixture was allowed to react for 24 h at room temperature. The product solution was diluted with deionized water, transferred to 3500 MWCO dialysis tubing (Spectrum) and dialyzed against deionized water (18 Mil) for 3 d. The retentate solution was clarified by filtration through Whatman No. 1 filter paper, concentrated with a rotary evaporator, and lyophilized to yield a colorless powder (0.435 g, 94%). The product was analyzed by 13C-NMR, FT-IR, SEC and MALDI-MS. The analytical data were consistent with the expected carboxylic acid-terminated product. 

Carnahan, M.A., Grinstaff, M.W., 2006. Synthesis of generational polyester dendrimers derived from glycerol and succinic or adipic acid. Macromolecules 39 (2), 609-616. 

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