Substances Derived from Bacteria, Plants, Insects, and Animals

1 Substances Derived from Bacteria, Plants, Insects, and Animals 

Only two compounds presently in the clinic act on unconventional targets oxazolidinones (which inhibit bacterial protein synthesis initiation by binding the 50S ribosomal subunit) and cationic peptides (which permeabilize bacterial membranes). 

An intriguing way of actually stimulating nature to deliver new biologically active molecules for drxrg development has been developed in the field of plants - more specifically by milking plant roots stimulated by bacterial and fungal elicitors.  

Easy transformation and cultivation make plants suitable for production of many recombinant proteins. Plants are capable of carrying out acetylation, phosphorylation and glycosylation as well as other post-translational protein modifications required for the biological activity of many eukaryotic proteins. Numerous heterologous (recombinant) proteins have been produced in plant leaves, frxrits, roots, tubers and seeds, and targeted to different subcellular compartments, such as the cytoplasm, endoplasmic reticuhrm or 

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