Sublingual immunotherapy pollen allergy

Roder E, Berger MY, Hop WC, Bernsen RM, de Groot H, Gerth van Wijk R. Sublingual immunotherapy with grass pollen is not effective in symptomatic youngsters in primary care. J Allergy Clin Immunol 2007 119(4) 892-8. [Epub 2007 Feb 23]. 

Specific immunotherapy is a very powerful tool which is currently underutilized in the treatment of allergies. Sublingual immunotherapy (SLIT) has many advantages over subcutaneous immunotherapy (SCIT), and has been well proven to work for many pollens and dust mites. Multiple studies have shown SLIT improves symptoms and reduces the reliance on medications. Sublingual treatment has been studied in Europe and is endorsed by the World Health Organization Committee on Immunotherapy as a viable alternative to SCIT. 

Clavel R, Andre C, Bousquet J Reduction of corticosteroid therapy by sublingual immunotherapy. Double blind study against placebo of standardised 5 grass pollen extract in rhinitis. Allergy 1995 50/26 279. 

Fanta C, Bohle B, Hirt W, Siemann U, Horak F, Kraft D, Ebner H, Ebner C Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy. Int Arch Allergy Immunol 1999 120 218-224. 

Vourdas D, Syrigou E, Potamianou P, Carat F, Batard T, Andre C, Papageorgiou PS Double-blind, placebo-controlled evaluation of sublingual immunotherapy with standardized olive pollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization. Allergy 1998 53 662-672. 

Marcucci F, Sensi L, Frati F, Senna GE, Canonica GW, Parmiani S, Passalacqua G Sublingual tryptase and ECP in children treated with grass pollen sublingual immunotherapy (SLIT) Safety and immunologic implications. Allergy 2001 56 1091-1095. 

Efficacy of Sublingual Immunotherapy in Grass Pollen Allergy... 

Sublingual immunotherapy SLIT Grass pollen allergy... 

Voltolini S, Modena P, Minale P, Bignardi D, Troise C, Puccinelli P, Parmiani S Sublingual immunotherapy in tree pollen allergy. Double-blind, placebo-controlled study with a biologically standardised extract of three pollens (alder, birch and hazel) administered by a rush schedule. Allergol Immunopathol 2001 29 103-110. 

Kinaciyan, T., B. Jahn-Schmid, A. Radakovics, B. Zwolfer, C. Schreiber, J. N. Francis, C. Ebner, and B. Bohle. 2007. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mai d 1. J Allergy Clin Immunol 119 (4) 937-943. 

Pradalier A, Basset D, Claudel A, Couturier P, Wessel F, Galvain S, Andre C Sublingual-swallow immunotherapy (SLIT) with a standardized five-grass-pollen extract (drops and sublingual tablets) versus placebo in seasonal rhinitis. Allergy 1999 54 819-828. 

Clavel R, Bousquet J, Andre C Clinical efficacy of sublingual-swallow immunotherapy A double-blind, placebo-controlled trial of standardized five-grass-pollen extract in rhinitis. Allergy... 

Quirino T, Iemoli E, Siciliani S, Parmiani S, Milazzo F Sublingual versus injective immunotherapy in grass pollen allergic patients A double blind (double dummy) study. Clin Exp Allergy 1996 26 1253-1261. 

Sabbah A, Hassoun S, Le Sellin J, Andre C, Sicard H A double blind placebo controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy 1994 49 309-313. 

Khinchi MS, Poulsen LK, Carat F, Andre C, Mailing HJ Clinical efficacy of sublingual-swallow and subcutaneous immunotherapy in patients with allergic rhinoconjunctivitis due to birch pollen. A double-blind, double-dummy placebo-controlled study. Allergy 2000 54(suppl 63) 24. 

La Rosa M, Ranno C, Andre C, Carat F, Tosca MA, Canonica GW Double-blind placebo-controlled evaluation of sublingual-swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 1999 104 425—432. Clavel R, Bousquet J, Andre C Clinical efficacy of sublingual-swallow immunotherapy A doubleblind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis. Allergy 1998 53 493-498. 

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