Subject aniline derivative

Other donors very often used in combination with fullerenes comprise ferrocene, phthalocyanine, transition metal complexes, aniline derivatives, tetrathiafulvalene and oligoacenes, carotenoids, oligoarylene, and oligothiophene and many examples are collected in recent reviews and books dedicated to this subject.3a,7e 28... 

This preliminary result has been the subject of an extensive study that confirms the catalytic nature of this rearrangement. It was observed that aniline derivatives do not undergo the rearrangement, probably because the aza-anion is more stabilized than... 

In an example illustrating an approach to tryptamines, the aniline derivative 98, which is available by a Heck reaction involving the corresponding o-iodoaniline, was subjected to rhodium-catalyzed hydroformylation leading to the target indole 99 via the intermediate 100 (Equation 26) <1997JOC6464>. 

Alkyl-substituted aryl bromides and triflates were subjected to react with aniline derivatives in the presence of NaOtBu as the base and provided the sp -amidation products in good to high yields. Substrates prone to oxidation or sensitive to acidic conditions were cleanly converted, underscoring the complementarity of the method. 

The combination of allylic amination, ring-closing metathesis, and a free radical cyclization provides a convenient approach to the dihydrobenzo[b]indoline skeleton, as illustrated in Scheme 10.10. The rhodium-catalyzed aUylic amination of 43 with the lithium anion of 2-iodo-(N-4-methoxybenzenesulfonyl)arrihne furnished the corresponding N-(arylsulfonyl)aniline 44. The diene 44 was then subjected to ring-closing metathesis and subsequently treated with tris(trimethylsilyl)silane and triethylborane to afford the dihydrobenzojhjindole derivative 46a in 85% yield [14, 43]. 

Cyclophosph(V)azanes with five-coordinate phosphorus are mostly dimeric, four-membered ring derivatives, [X3PNR]2 (6). Several reviews cover the subject. A simple preparation of these compounds involves the reaction of PCI5 with primary amines (or their hydrochlorides), the so-called Kirsanov reaction. Weakly basic amines form monomeric Cl3P=NR, but with more basic amines (e.g. with R = alkyl), the products are the cyclic dimers. Various anilines give either a monomer or a cychc dimer, depending upon their basicity. ... 

Theories of Formation of Benzene, etc.—Theories of the formation of these benzene products in the distillation of coal have been investigated principally by Berthelot, and his conclusions are, in general In the first place, coal decomposes by heat yielding simple paraffin compounds such as methane, ethylene, acetylene, alcohol, acetic acid, etc. These compounds when subjected to higher temperatures polymerize into benzene, and the higher hydrocarbons naphthalene, anthracene, phenanthrene, etc., and into derivatives of these such as phenol, aniline, pyridine, etc. 

In the laboratory of R. Bihovsky, a series of peptide mimetic aldehyde inhibitors of calpain I was prepared in which the P2 and P3 amino acids were replaced with substituted 3,4-dihydro-1,2-benzothiazine-3-carboxylate-1,1-dioxides. The synthesis began with the diazotization of the substituted aniline substrate using sodium nitrite and hydrochloric acid. The aqueous solution of the corresponding diazonium chloride product was added dropwise to the solution of acrylonitrile in a water-acetone mixture, which contained catalytic amounts of copper(ll) chloride. This Meerwein arylation step afforded the chloronitrile derivative, which was subjected to sulfonation with chlorosulfonic acid, and the resulting sulfonyl chloride was treated with the solution of ammonia in dioxane to give the desired 3,4-dihydro-1,2-benzothiazine-2-carboxamide. 

Laurent and Erdmann oxidized isatin, from which they obtained anthranilic acid (4). Carl Julius Fritzsche (also known as Iulii Federovich Fritsshe) in 1840 subjected anthranilic acid to alkaline distillation and obtained a powerful base, devoid of oxygen , that he called Anilin, from anil, the Portuguese word for indigo, which in turn had been derived from Arabic and Sanskrit. In 1842, the Russian chemist Nikolai N. Zinin reduced, with hydrogen sulfide, Nitrobenzid (nitrobenzene) to what was called Benzid (also Benzidam,... 

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