Phthalimide Potassium

Phthalimide, potassium [ 1H Isomdole-l,3(2//)-dione, potassium salt], 96 Phth-Gly.Gly-OEt [Glycine, N [(1,3-dihydro-1,3-dioxo-2//-isoindol-2-yl)acelyl], ethyl ester], 93 a-Pinene [Bicyclo 3.1.1]hept 2-ene,... 

The 7-bromopropylphthalimide was prepared from potassium phthalimide and trimethylene bromide in 78% yields, using the conditions and molar quantities specified for the preparation of (3-bromoethylphthalimide.1 7-Bromopropylphthalimide can also be prepared from phthalimide, potassium carbonate, and trimethylene bromide.2... 

Yield.—Almost theoretical M.P. 118°. (B., 19,2991 0. S., XIII., 82.) Reaction CXXV. Action of Alkyl Halides on Phthalimide (Potassium Salt). —When an alcoholic solution of phthalimide is treated with the theoretical quantity of caustic potash dissolved in alcohol, a crystalline compound—potassium phthalimide—separates out (see p. 427). 

The facile alkylation of phthalimide and subsequent hydrolysis of the N-substituted derivatives furnishes a convenient synthesis for primary amines. The substituted phthalimide was originally prepared by heating a mixture of phthalimide, potassium carbonate, and organic halide in a non-polar solvent for 2 to 24 hours at 100° to 150°. An improved procedure consists in performing this initial step in a polar solvent like dimethylformamide, in which potassium phthalimide is appreciably soluble the reaction occurs at room temperature within 10 minutes. Various esters of p-toluenesulfonic acid may be substituted for the organic halides as alkylating agents. ... 

EINECS 214-046-6 HSDB 5781 N-Potassiophthallmide N-Potassium phthalimide NSC 167070 Phthalimide, potassium salt Potassium phthalimidate Potassium phthalimide. 

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