Study coordinator, responsibilities

The study coordinator is generally considered the linchpin in the day-to-day activities of clinical research. Without this key individual, sites would be hard pressed to perform studies in a quality and timely fashion because the coordinator s responsibilities define clinical trial conduct. 

Assign responsibilities and establish deadlines and milestones for all personnel closely related to the study (e.g., study coordinator, coinvestigators, research fellows). 

The written protocol should not only contain information about the batches, packages, tests, specifications, and testing schedule, but also should indicate the responsibility of the study coordinator and the analytical testing laboratories involved, if it is not already defined in SOPs. The means of data tabulation and data evaluation, including the statistical analysis to be... 

The aim of this chapter is to describe and to put in perspective the most recent results of gas-phase p.e. studies of coordination complexes containing f-elements. The discussion, however, will be mainly concerned with organometallic complexes because the recent growth in organometallic chemistry of the f-eleraents [1] has spurred on p.e. studies in response to the need for a better understanding of interactions between organic ligands and f metals [2]. 

Thus, they concluded that ATP-sulfurylase was subject to feed-forward stimulation by a reaction product of nitrate reduction and that nitrate reductase was subject to an analogous feed forward by a product of sulfate, thus coordinating the first step of each of the two pathways. Some support for this mechanism has come fi om experiments with cell cultures of Ipomea (Zink, 1984) and from measurements of ATP-sulfurylase and nitrate reductase in the leaves of whole tobacco plants (Barney and Bush, 1985), though in the latter study the response of ATP-sulfurylase to nitrogen stress was far less pronounced than the response of nitrate reductase to sulfur stress. However, as discussed below, APS sulfo-transferase rather than ATP-sulfurylase appears to be the principal determining site for the feed-forward control of sulfate assimilation by nitrogen assimilation products in Lemna. 

Experimental confirmation of the metal-nitrogen coordination of thiazole complexes was recently given by Pannell et al. (472), who studied the Cr(0), Mo(0), and W(0) pentacarbonyl complexes of thiazole (Th)M(CO)5. The infrared spectra are quite similar to those of the pyridine analogs the H-NMR resonance associated with 2- and 4-protons are sharper and possess fine structure, in contrast to the broad, featureless resonances of free thiazole ligands. This is expected since removal of electron density from nitrogen upon coordination reduces the N quad-rupole coupling constant that is responsible for the line broadening of the a protons. 

Many errors have occurred due to failure to explicitly allocate responsibility between different individuals who need to coordinate their efforts. This is illustrated by the case study in this section. 

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