Stuart Prower factor

X Stuart-Prower factor Heparin (Xa) warfarin (synthesis)... 

X Stuart-Prower factor (= constituent of F II activator) + + 20-42 hours... 

The accepted mechanism for vitamin K is to function as a cofactor in the posttranslational synthesis of y ar-boxyl-glutamic acid (Glu) from glutamic acid residues. The discovery of Gla in 1974 - clarified the mechanism of vitamin K and led to the identification of additional vitamin K-dependent proteins. The only known function of vitamin K in mammals is to maintain adequate levels of vitamin K-dependent proteins involved in coagulation. The.se include prothrombin (factor II). factor VII (proconvertin), factor IX (autoprothrombin II). factor X (Stuart-Prower factor), and proteins C. S. and Z. Prothrombin and factors VII. IX. and X promote coagulation, while proteins C and S have anticoagulant activity. The function of protein Z is not known. 

Stuart-Prower factor (Autoprothrombin III) X Factor X deficiency Very rare 8 0.15 Liver 24-50 lAPO, ICCF, IFAX, IHCG, IKIG, IWHE, IWHF FA10 HUMAN... 

The conformational change in antithrombin III induced by heparin allows the molecule to bind to, and inactivate, factors involved in the clotting cascade. Primary factors affected are the activated forms of factor IX ( Christmas factor, or plasma thromboplastin component) and X ( Stuart-Prower factor ). 

Stuart-Factor, Stuart Prower-Factor, Thrombokinase, Factor X... 

Stuart-Factor, Stuart Prower-Factor, Thrombokinase, Factor X, a serine protease and constituent of the blood coagulation cascade. It is either be activated by factor IX (intrinsic pathway) or by Factor Vila (extrinsic pathway). In complex with Factor V as the cofactor it cleaves prothrombin at Arg-Thr and Arg-Ile to give active thrombin. 

The coumarin anticoagulants are employed in therapy to depress blood coagulation and to prevent thrombosis in diseases of the coronary artery and in other conditions [419]. These compounds act only in vivo by blocking the synthesis of four proteins in the prothrombin complex (factors II = prothrombin, VII = proconvertin, IX = plasma thromboplastin component, and X = Stuart-Prower factor) necessary for the normal blood coagulation process. These proteins are... 

Intrinsic thromboplastin is formed in three steps. The first step involves the plasma thromboplastin component the antihemophilic globulin, the thromboplastin antecedent (PTA), the Hageman factor, and the Stuart-Prower factor. All these factors interact rapidly they have not been purified, and therefore nothing is known of their molecular structure. With so little information, it would be rather naive to anticipate that the exact mode of interaction of these different factors would be known. 

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