Antihemophilic globulin

Proconvertin, serum prothrombin conversion accelerator (SPCA), cothromboplastin Antihemophilic factor A, antihemophilic globulin (AHG)... 

Factor VIII. Originally known as antihemophilic globulin, Factor VIII is a very large glycoprotein complex of two different molecular units... 

Hageman factor (XII), antihemophilic globulin (VIII), Christmas factor (IX), plasma thromboplastin antecedent (XI), calcium (IV), and platelet phospholipids... 

Pool, J. G. and Shannon, A. E. (1965). Production of high-potency concentrates of antihemophilic globulin in a closed-bag system. N. Engl. J. Med. 273, 1443-1447. 

VIII Antiltcmttphilic factor, antihemophilic globulin, platelet cofactor 1. antihenmpbillc factor A... 

A2. Adelson, E., Rheingold, J. J., Parker, 0., Steiner, M., and Kirby, J. C., The survival of factor VIII (antihemophilic globulin) and factor IX (plasma thromboplastin component) in normal humans. J. Clin. Invest. 42, 1040-1047 (1963). 

Rapaport, 8. I., Schiffman, 8., Patch, M. J., and Ames, 8. B., The importance of activation of antihemophilic globulin and proaccelerin by traces of thrombin in the generation of intrinsic prothrombinase activity. Blood 21, 221-236 (1963). 

The antihemophilic globulin, the factor absent from the blood in the best-known hemophilia, combines stoichiometrically with a platelet thromboplastic factor, and the two compounds act like precursors, yielding a product itself a precursor. For thromboplastin, the product is prothromboplastin. The platelet thromboplastin component acts like a catalyst consequently, its concentration does not change during the reaction. The prothromboplastin combines with another compound called the plasma-accelerating globulin to yield a new product, namely, thromboplastin. 

Intrinsic thromboplastin is formed in three steps. The first step involves the plasma thromboplastin component the antihemophilic globulin, the thromboplastin antecedent (PTA), the Hageman factor, and the Stuart-Prower factor. All these factors interact rapidly they have not been purified, and therefore nothing is known of their molecular structure. With so little information, it would be rather naive to anticipate that the exact mode of interaction of these different factors would be known. 

Antihemophilic globulin AHG Factor VIII plasma thromboplas-tic factor antihemophilic globulin A thrombocytolysin thromboplastinogen plasmatic cofactor of platelets coagulase globulin... 

Von Willebrand s disease was at first thought to result from a failure of capillary function. Later it was demonstrated that patients affected by this disease lack antihemophilic globulin, which explains the new name for the disease—vascular hemophilia. The condition seems to be inherited as an autosomal dominant trait. It is not known whether the capillary deficiency and the deficiency in antihemophilic globulin are inherited simultaneously or separately. Other combined deficiencies have been described in very few patients. Some examples of combined deficiencies are deficiency of AHF and PTC, AHF and factor V, PTC and SPCA (these situations are rare and sometimes very difficult to describe), and AHF and PTA. 

Precursor of serum prothrombin conversion accelerator Prothrombin Accelerator globulin Antihemophilic globulin... 

Synonyme (l) Antihemophilic Globulin Thromboploetinogen Thrombocytolyein Plotmo... 

Clotting may be inhibited or disturbed in several ways. The well-known bleeding condition hemophilia is caused by the absence (or inactivity) of any one component of the thrombokinase system from blood, i.e. of some plasma factor. In classical hemophilia A it is factor VIII (antihemophilic globulin) in hemophilia B, factor IX (Christmas factor). Due to a deficiency in these factors insufficient amounts of plasma thrombokinase are formed, and consequently the transition prothrombin —> thrombin is delayed greatly or even prevented. 

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