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Stromal keratitis, herpes simplex

Efficacy In other conditions The clinical efficacy in the treatment of stromal keratitis and uveitis caused by herpes simplex or ophthalmic infections caused by vaccinia virus and adenovirus, or in the prophylaxis of herpes simplex virus keratoconjunctivitis and epithelial keratitis has not been established by well-controlled clinical trials. Not effective against bacterial, fungal, or chlamydial infections of the cornea or trophic lesions. [Pg.2111]

Herpesviruses range in size from 120 to 300 nm and have DNA genomes and outer lipid membranes (envelopes). As enveloped viruses, herpesviruses are sensitive to drying and adverse conditions. Herpesviruses are spread by inoculation of susceptible mucous membranes or direct cell-to-cell contact. Over 100 herpesviruses have been identified, but only 5 cause human eye infections with any frequency herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus. Herpesviruses can cause blepharitis, conjunctivitis, epithelial and stromal keratitis, uveitis, retinitis, and ARN. HSV-1 is the most frequent cause of primary and recurrent eye disease. The host immime system influences the rates of reactivation. Immimocompromised patients tend to have more frequent reactivations and more severe disease manifestations. The strain of virus also affects the... [Pg.196]

Barron BA, Gee I, Hanuck WW, et al. Herpetic eye disease smdy. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. Ophthalmology 1994 101 1871-1882. [Pg.217]

Herpetic Eye Disease Smdy Group l.A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex vims epithelial keratitis. Arch Ophthalmol 1997 115 703-712. [Pg.218]

Herpetic Eye Disease Study Group. Oral acyclovir for herpes simplex virus eye disease effect on prevention of epithelial keratitis and stromal keratitis. Arch Ophthalmol 2000 118 1030-1036. [Pg.414]

Herpes Simplex Virus Ophthalmia Neonatorum. HSY infection is an uncommon but important cause of neonatal infection and is associated with conjunctivitis in 5% to 10% of cases.The clinical manifestations are nonspecific and include conjimctival hyperemia, chemosis, periorbital edema, and mucous discharge. Corneal involvement is not uncommon and can include dendritic, geographic, or stromal keratitis. Herpetic ophthalmia neonatorum represents a primary herpetic infection. Central nervous system involvement, encephalitis, retinitis, optic neuritis, uveitis, choroiditis, and a fetal viremia can be serious sequelae of primary herpetic infections. [Pg.462]

Idoxuridine, which is active against Herpes simplex and Varicella zoster, has only been used in topical antiherpetic solutions. Idoxuridine has been used to treat superficial keratitis, but with poor results in deep stromal diseases because of poor solubility. However, idoxuridine is unstable and cannot eliminate the virus from the eye. Drug allergy and toxicity occur in 5-8% of patients. [Pg.1713]

Knickelbein JE, Hendricks RL, Chamkamnoetkanok P. Management of herpes simplex vims stromal keratitis an evidence-based review. Surv Ophthalmol 2009 54(2) 226—34. [Pg.520]

Farooq AV, Shukla D. Herpes simplex epithelial and stromal keratitis an epidemiologic update. Surv Ophthalmol 2012 57(5) 448—62. [Pg.520]


See other pages where Stromal keratitis, herpes simplex is mentioned: [Pg.533]    [Pg.1101]    [Pg.1881]   
See also in sourсe #XX -- [ Pg.528 ]




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Herpes keratitis

Herpes simplex

Herpes simplex keratitis

Keration

Keratitis

Simplexes

Stromal

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