Temperature control stroke

Hypothermia is known to cause cardiac dysfunction, particularly arrhythmias (36,37). Careful temperature control and optimal antiar-rhythmic therapy can minimize this problem. However, to avoid severe circulatory dysfunction, knowledge of arrhythmias is required. Hypothermia may be associated with a suppression of the immunological system, which exposes patients to the danger of severe infections. Schwab et al. reported that 7 of 25 stroke patients undergoing hypoth-ermiatherapy suffered a septic syndrome (17). In our hypothermic study, none of the 13 patients who underwent hypothermia therapy for 3-7 d developed severe infectious diseases. However, the remaining patient, who underwent 10 d of hypothermia because of massive cerebral edema, developed septic shock on the 10th day of hypothermia treatment. The immunosuppressive effect appears to be correlated with the depth and... 

The two valves being adjusted by the temperature controller are implemented such that their stroking fully overlaps, with one valve closing as the other valve opens, as shown in Figure 3.8(C). With smaller pipe sizes, these two valves could economically be replaced with a three-way valve located at the start of the bypass line. It should not be located at the end of the bypass line where thermal stresses would exist from the two different temperature streams. The three-way valve has flow characteristics similar to... 

Heat stroke results from a failure of the body s temperature control system resulting in a core body temperature greater than 105°F or 40.6°C. In addition to fainting symptoms may include the following ... 

A study by Georgiadis et al. (31) induced hypothermia (target temperature 33°C) in 14 patients with an acute anterior circulation infarction involving at least two thirds of the left MCA territory. Patients received norepinephrine via continuous intravenous infusion and were mechanically ventilated. Hypothermia was initiated 26 h after onset of symptoms as a means to control intracranial hypertension and not for neuroprotection. In that study, static cerebral autoregulation did not appear impaired in the unaffected hemisphere with the use of alpha-stat for pH maintenance. However, the main concern in patients with acute stroke is the perfusion of the affected hemisphere, specifically of the penumbra (18). 

Reactor and Reactor Conditions. A 5-litre glass reactor (15 cm diameter) fitted with four stainless steel baffles (10 cm x 1.5 cm) immersed in a thermostatted oil bath at 80 °C (reflux temperature of methyl acrylate) was used for polymerisation. Stirring was by means of a marine type impeller (6 cm diameter and pitch 45°). The overall reaction rate was sufficiently slow to ensure isothermal conditions. Additions of solutions of the more reactive monomer (styrene, of molar concentration 0.8) to the reactor were made using a computer controlled positive displacement pump (Precision Metering Ltd.) with four long-stroke pump heads, 90 out of phase to minimise pulsation of the flow. 

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