Autoregulation of cerebral

Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, et al. 2000. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res 87 60-65. 

Dirnagl U, Pulsinelli W (1990) Autoregulation of cerebral blood flow in experimental focal brain ischemia. J Cereb Blood Flow Metab 10 327-336... 

Nervous System Halothane dilates the cerebral vasculature, increasing cerebral blood flow under most conditions. This increase in blood flow can increase intracranial pressure in patients with space-occupying intracranial masses, brain edema, or preexisting intracranial hypertension. Thus, halothane is relatively contraindicated in patients at risk for elevated intracranial pressure. Halothane also attenuates autoregulation of cerebral blood flow. 

Harper, A.M., Autoregulation of cerebral blood flow influence of the arterial blood pressure on the blood flow through the cerebral cortex. J Neurol Neurosurg Psychiatry, 1966. 29(5) p. 398-403. 

Captopril is the fastest of the oral ACE inhibitors. It can also be used sublingually in patients who cannot swallow. Captopril shifts the entire curve of cerebral autoregulation in such a way that cerebral blood flow is maintained as the systemic pressure falls. Caution is needed in patients with significant renal... 

Jalan R., Olde Damink S. W., Deutz N. E., Hayes P. C., and Lee A. (2001) Restoration of cerebral blood flow autoregulation and reactivity to carbon dioxide in acute liver failure by moderate hypothermia. Hepatology 34,50-54. 

Traon AP, Costes-Salon MC, Galinier M et al. (2002). Dynamics of cerebral blood flow autoregulation in hypertensive patients. Journal of Neurology Science 195 139-144 van der Grond J, Eikelboom BC, Mali WPThM (1996). Flow-related anaerobic metabolic changes in patients with severe stenosis of the internal carotid artery. Stroke 27 2026-2032... 

Hardy, P., Varma, D.R., Chemtob, S. (1997). Control of cerebral and ocrdar blood flow autoregulation in neonates. Pediatr. Clin. N. Am. 44 137-52. 

Accelerated phase hypertension was previously called malignant hypertension because the lack of treatment heralded death within a year of diagnosis. It is characterised pathologically by fibrinoid necrosis of the small arteries. An important consequence is the loss of autoregulation of the cerebral and renal circulation, so that any reduction in blood pressure causes a proportional fall in perfusion of... 

Studies of Cerebral Tissue Oxygenation and Related Autoregulation... 

PRES is a syndrome that results from loss of cerebral autoregulation and capillary leakage in association with a variety of clinical entities including acute hypertension preeclampsia and eclampsia septic shock autoimmune diseases such as systemic lupus erythematosus and Wegener granulomatosis treatment with immunosuppressive agents snch as cyclosporin and tacrolimus treatment with chemotherapentic agents such as intrathecal... 

Ursino, M., and Giulioni, M. (2003) Quantitative assessment of cerebral autoregulation from transcranial Doppler pulsatility a computer simulation study. Med. 

Bodo, M., Pearce, F.J., Baranyi, L., Armonda, R.A., 2005a. Changes in the intracranial rheoencephalogram at lower limit of cerebral blood flow autoregulation. Physiol. Meas. 26, SI—S17. 

Panerai, R.B. (1998) Assessment of cerebral pressure autoregulation in humans-a review of measurement methods. Physiological Measurement 19 305-338. 

Blaber, A.P., Bondar, R.L., Stein, F., Dunphy, P.T., Moradshahi, P., Kassam, M.S., Freeman, R. (1997) Transfer function analysis of cerebral autoregulation dynamics in autonomic failure patients. Stroke 28 1686-1692. 

Chiu, C.C., Yeh, S.J., liau, B.Y. (2005) Assessment of cerebral autoregulation dynamics in diabetics using time-domain crosscorrelation analysis. Journal of Medical and Biological Engineering... 

Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ. Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage a phase II randomized placebo-controlled trial. Stroke 2005 36 1627-1632. 

Sevoflurane has a dose-dependent effect on cerebral blood flow and intracranial pressure cerebral autoregulation is preserved (this is not the case with isoflurane). During hypocarbia, in the absence of nitrous oxide, 1 MAC does not increase intracranial pressure (ICP). It reduces the cerebral metabolic rate for oxygen (CMR02) by approximately 50% at concentrations approaching 2 MAC. This is similar to the reduction observed during isoflurane anaesthesia. 

---