Stress-induced hyperthermia test

Chinese angelica Angelica sinensis) is the most important female tonic remedy in Chinese medicine. The elfects of angelica EO in three assays in mice (elevated plus maze, light/dark and stress-induced hyperthermia test) suggested that angelica EO exhibited an anxiolytic-like effect [391]. A link to emotion and cognitive performance with the olfactory system was reported [392]. Moreover, the EOs could affect mood, concentration and sleep [393], while other studies had shown that EOs were potentially important to boost the immune system [394, 395]. 

Iijima, M., Shimazaki, T., Ito, A. and Chaki, S. (2007) Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hyperthermia test in singly housed mice. Psychopharmacology, 190, 233-239. 

Rose and lavender oil, administrated intraperitoneally (ip) to mice, showed anticon ict effects (Umezu 1999 Umezu et al. 2002), suggesting anxiolytic properties. Unequivocal anxiolytic properties were also demonstrated for lavender EO (ip, gerbils) with the elevated plus maze test (Bradley et al. 2007). Chen et al. (2004) reported Xh i Angelica sinensis (Oliv.) Diels (Apiaceae) EO (orally administrated, mice) also has an anxiolytic effect in the elevated plus maze, the light/dark model, and the stress-induced hyperthermia paradigms. 

While most strains respond consistently to this paradigm due to its independence from motor activity, specific mouse strains (e.g., FVB/N) have considerably higher baseline body temperatures and should be avoided in this model (21). However, this procedure has been shown to effectively induce hyperthermia to varying degrees in all inbred and outbred strains tested (41) and is also an effective indicator of stress in genetically modified animals (34). 

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