Streptococcus pyogenes superantigens

Streptococcus pyogenes and Staphylococcus aureus secrete a number of enterotoxins and pyrogenic exotoxins, respectively. These toxins are known as superantigens, since they simultaneously form complexes with the major histocompatibility class II (MHC-II) molecules and T-cell receptors (TCRs) enabling them to activate a number of T-cell lymphocytes. Thus, superantigens stimulate up to... 

Mollick JA, Miller GG, Musser JM, Cook RG, Grossman D, Rich RR A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C. J Clin Invest 1993 92 710-719. 

Kamezawa Y, Nakahara T, Nakano S, Abe Y, Nozaki-Renard J, Isono T Streptococcal mitogenic exotoxin Z, a novel acidic superantigenic toxin produced by a T1 strain of Streptococcus pyogenes. Infect Immun 1997 65 3828-3833. 

Gerlach D, Fleischer B, Wagner M, Schmidt K, Vettermann S, Reichardt W Purification and biochemical characterization of a basic superantigen (SPEX/SMEZ3) from Streptococcus pyogenes. FEMS Microbiol Lett 2000 188 153-163. 

Proft T, Moffatt SL, Berkahn CJ, Fraser JD Identification and characterization of novel superantigens from Streptococcus pyogenes. J Exp Med 1999 189 89-101. 

Arcus VL, Proft T, Sigrell JA, Baker HM, Fraser ID, Baker EN Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus pyogenes. 1 Mol Biol 2000 299 157-168. 

Unnikrishnan M, Altmann D, Proft T, Wahid F, Cohen J, Fraser J, Sriskandan S The bacterial superantigen streptococcal mitogenic exotoxin Z is the major immunoactive agent of Streptococcus pyogenes. J Immunol 2002 169 2561-2569. 

Smoot LM, McCormick JK, Smoot JC, Hoe NP, Strickland I, Cole RL, Barbian KD, Earhart CA, Ohlendorf DH, Veasy LG, Hill HR, Leung DYM, Schlievert PM, Musser JM Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks. Infect Immun 2002 70 7095-7104. 

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