Tumorigenicity stem cells

Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells Bums, J.S., Abdallah, B.M., Guldberg, P., Rygaard, J., Schroder, H.D., Kassem, M.(2005). Cancer Res, 15 65 (8) 3126-3135. 

Tumorigenicity studies are also needed for certain cell therapy products based on the specific product attributes and clinical indications. Somatic cell therapy includes cells from various sources such as adult cells derived from the individual being treated (autologous), cells donated from one human to another (allogeneic), and cells from an animal source and used for human treatment (xenogeneic). Stem cell therapy includes cells derived from a variety of adult... 

One of the greatest concerns about using undifferentiated stem cells is their potential to develop tumors [67,68]. The investigation of immortalization, malignant transformation, and tumorigenicity, however, are unlikely to be addressed by conventional rodent bioassays for carcinogenicity or the alternative short-term transgenic mouse assays (see Table 33.7). 

Monocytic leukemia zinc hnger protein, a histone acetyltransferase implicated in leukemogenic and other tumorigenic processes, regulates expression of genes required for proliferation and repopulation of potential of stem cells in the hematopoietic compartment... 

Al-Hajj M, Wicha MS, Benito-Hemandez A, Morrison SJ, Clarke ME. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003 100 3983-3988. Morrison BJ, Schmidt CW, Lakhani SR, Reynolds BA, Lopez JA. Breast cancer stem cells implications for therapy of breast cancer. Breast Cancer Res 2008 10 210. 

Fang D, Nguyen TK, Leishear K et al. (2005) A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 65 9328-9337... 

Resveratrol could also affect cancer stem cells based on cancer stem cell theory [153]. This theory asserts that several human cancers are initiated from and maintained by a very small population of tumorigenic cells that are capable of continuous self-renewal which produces the tumor mass. Indeed, resveratrol modulates two major pathways playing a pivotal role in cancer stem cell self-renewal [153]. 

Tumorigenicity In a case report, donor bone marrow-derived stem cells produced an oral squamous cell carcinoma composed of donor cells 2 years after transplant [178 ]. 

Park, K. D., Seong, S. K., Park, Y. M., Choi, Y, Park, J. H., Lee, S. H., Baek, D. H. et al. 2011. Telomerase reverse transcriptase (TERT) Related with Telomerase Activity Regulates Tumorigenic Potential of Mouse Embryonic Stem Cells. Stem Cells Dev, 20 149-57. 

Ponti D, Costa A, Zaffaroni N et al (2005) Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 65 5506-5511... 

The v-erbB oncogene acts to expand a pool of highly mitotic, undifferentiated erythroid precursor cells, but these are poorly tumorigenic, because they differentiate at high rates into postmitotic, end-stage red cells. Another potential oncogene, v-erbA, blocks differentiation of erythroid precursors but creates no tumors because it is unable to provide the mitogenic impetus needed to expand the pool of stem... 

Patrawala L, Calhoun T, Schneider-Broussard R et al. (2005) Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2 + and ABCG2- cancer cells are similarly tumorigenic. Cancer Res 65 6207-6219... 

Wnt/P-catenin signaling plays an important role in the maintainance of liver CSCs. For example, elevated expression of Wnt and its downstream mediators are shown in EpCAM+ liver CSCs. It has been demonstrated that murine hepatic stem/ progenitor cells transduced with mutant P-catenin can acquire excessive self-renewal capability and tumorigenicity. 

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