Stem cell adhesion

Montero-Pancera, S., Trouillet, V., Petershans, A., Fichtner, D., Lyapin, A., Bruns, M., Schimmel,T., WedUch, D., Reichlmaier, S., Weidler, P.G., Gliemann, H. (2010) Design of chemically activated polymer microwells by one-step UV-lithography for stem cell adhesion. Langmuir, 26,2050-2056. 

With respect to hyaluronic acid, direct hyaluronic-based HG injection into Ml rats resulted in improved heart function, LV remodeling, and new vasculature formation compared to nontreated animals [81]. Moreover, hyaluronic acid HGs are able to release growth factors in a controlled manner for more than 1 week, thus enhancing the remodeling of the infarcted myocardium [82], providing a favorable microenvironment for stem cell adhesion, proliferation, and differentiation toward cardiac cells and thereby improving cardiac performance [83]. 

Song K, Wen P, Liu T. Bio-derived bone surface modification with biomimetic thin film coatings to improve mesenchymal stem cells adhesion and spreading. Key Eng Mater 2008 373 722. 

Lin, Y-C, Brayfield, CA, Gerlach, JC, Peter Rubin, J, and Marra, KG. 2009. Peptide modification of poly-ethersulfone siufaces to improve adipose-derived stem cell adhesion. Acta Biomater 5(5) 1416-1424. 

Ragetly G, Griffon DJ, Chung YS (2010) The effect of type II collagen coating of chitosan fibrous scaffolds on mesenchymal stem cell adhesion and chondrogenesis. Acta Biomater... 

The CaR regulates numerous biological processes, including the expression of various genes (e.g., PTH) the secretion of hormones (PTH and calcitonin), cytokines (MCP-1), and calcium (e.g., into breast milk) the activities of channels (potassium channels) and transporters (aquaporin-2) cellular shape, motility (of macrophages), and migration cellular adhesion (of hematopoietic stem cells) and cellular proliferation (of colonocytes), differentiation (of keratinocytes), and apoptosis (of H-500 ley dig cancer cells) [3]. 

Fig. 1. Surface phenotype of HSPCs. Primitive HSPCs have the phenotype of c-KitThy-ll0WLin CD34+CD33 in humans, and the mouse counterparts have the phenotype of c-KifThy-llowLin Sca-l+. Primitive HSPCs express CXCR4 as the major chemokine receptor and various adhesion molecules such as VLA-4, VLA-5, LFA-1, P-selectin glycoprotein ligand-1 (PSGL-1), and CD44 for migration to the stem cell niche.

Fapidot T, Petit I. Current understanding of stem cell mobilization the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 2002 30(9) 973-981. 

Keywords Amphiphilic polymer Cell adhesion Chimeric protein Islet of Langerhans Self-assembled monolayer Stem cell... 

Knowledge gained from cell adhesion studies with SAMs has been used to develop culture substrates with the appropriate cell adhesion glycoproteins for different types of cells [7-10], Stem cells, capable of self-renewal and differentiation into multiple cell types, are found in embryonic and adult tissues. Pluripotent stem cells, like embryonic stem cells and induced pluripotent stem cells, have been developed in vitro. These cells are expected to provide cell sources for regenerative medicine. Various culture conditions have been developed to enable expansion of these cells without loss of their multi- and pluripotency and to induce differentiation into viable cells with specific functions. 

The Xi02 nanotube arrays are also well suited for hosting and stabilizing bio-catalysts. Hemoglobin could be immobilized in Xi02 nanotube films and be used as bio-catalyst. It was also observed that adhesion, spreading, growth, and difierentiation of mesenchymal stem cells are critically dependent on the tube diameter. ... 

---