Staphylococcus aureus transduction

The ease with which different bacteria acquire resistance varies. For example, Staphylococcus aureus is notorious for its ability to acquire drug resistance due to the ease with which it can undergo transduction. On the other hand, the microorganism responsible for syphilis seems incapable of acquiring resistance and is still susceptible to the original drugs used against it. 

The crude organic extracts of a Penicillium sp. isolated from a depth of 885 ft. were active against Staphylococcus aureus and in the brine shrimp lethality screen. These extracts were further tested using enzyme inhibition assays for two different signal transduction enzymes - matrix metalloproteinase-3 (MMP-3) and caspase-1 (Casp-1). Compounds 13 and 14 were isolated from the chloroform extracts of the broth filtrate of a Penicillium sp. found growing in Berkeley Pit Lake. Berkeleydione (13, 5.5 mg/L) was isolated as a crystalline... 

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