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Enzyme inhibition assays

Inhibition values quoted in this chapter are those from enzyme inhibition assays. [Pg.118]

Several higher throughput in vitro assays may be used to assess various DMPK properties of NCEs. One common parameter is that HPLC/MS/MS is the method of choice for the analytical step.11 17 26 These higher throughput assays include the Caco-2 assay, p450 enzyme inhibition assay, and in vitro stability assay. Each assay has different requirements and solutions and they will be described individually. [Pg.207]

Irth H Continuous-flow systems For ligand binding and enzyme inhibition assays based on mass spectrometry, chapter 5. [Pg.182]

Continuous-flow Systems for Ligand Binding and Enzyme Inhibition Assays Based on Mass Spectrometry... [Pg.185]

The assay principle for MS-based enzyme inhibition assay is shown in Fig. 5.1. The assay is based on the mass spectrometric detection of reaction products of... [Pg.186]

P.W. Alexander and G.A. Rechnitz, Enzyme inhibition assays with an amperometric glucose biosensor based on thiolate self-assembled mono-layer, Electroanalysis, 12 (2000) 343-350. [Pg.308]

H. Mohammadi, A. Amine, S. Cosnier and C. Mousty, Mercury-enzyme inhibition assays with an amperometric sucrose biosensor based on a trienzymatic-clay matrix, Anal. Chim. Acta, 543 (2005) 143-149. [Pg.310]

See other pages where Enzyme inhibition assays is mentioned: [Pg.521]    [Pg.205]    [Pg.208]    [Pg.208]    [Pg.208]    [Pg.186]    [Pg.405]    [Pg.406]    [Pg.125]    [Pg.56]    [Pg.90]    [Pg.90]    [Pg.262]    [Pg.298]    [Pg.20]    [Pg.292]    [Pg.1106]    [Pg.314]    [Pg.101]    [Pg.355]   
See also in sourсe #XX -- [ Pg.208 , Pg.239 ]

See also in sourсe #XX -- [ Pg.405 ]

See also in sourсe #XX -- [ Pg.171 ]



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Systems for Ligand Binding and Enzyme Inhibition Assays Based on Mass Spectrometry

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