Stable Isotope Dilution Mass Spectrometry

Dizdaroglu, M. (1993). Quantitative determination of oxidative base damage in DNA by stable isotope-dilution mass spectrometry. FEBS Lett. 315, 1-6. 

Pickup JF, McPherson K. 1976. Theoretical considerations in stable isotope dilution mass spectrometry for organic analysis. Anal Chem 48 1885-1890. 

System (3) described the use of stable-isotope-dilution mass spectrometry for the simultaneous determination of cortisol, cortisone, prednisolone, and prednisone in plasma [177]. Cortisol, cortisone, prednisolone, and prednisone were simultaneously extracted from acidified plasma on a Sep-Pak Ci8 cartridge. The column was eluted with methanol, the eluent evaporated, and the residue compounds reacted to their bismethylenedioxy-3-heptafluoro-n-butyryl derivatives by treatment with formaldehyde and heptafluoro-n-butyric anhydride. The derivatives were... 

Yokokawa A, Yamamoto K, Omori Y, Shibasaki H, Shinohara Y, Kasuya Y, Furuta T (2009) Simultaneous determination of androstenedione, 1 lb-hydroxyandrostenedione, and testosterone in human plasma by stable isotope dilution mass spectrometry. J Chromatogr B 877 621-626... 

W. R. Wolf, H. Zainal, Methylseleno-amino acid content of food materials by stable isotope dilution mass spectrometry, Food Nutr. Bull., 23 (2002), 120D123. 

Varelis P, Smythe GA, Hodgson D, Lazarus L. Measurement of urinary free cortisol by stable isotope dilution mass spectrometry using a new cortisol derivative. J Chromatogr B Biomed Appl 1994 660 151-9. 

Minor Methoxypyrazines. Stable isotope-dilution mass spectrometry has also allowed quantitative analysis of 2-methoxy-3-(l-methylpropyl)pyrazine (2) sec-butylmethoxypyrazine) and 2-methoxy-3-(l-methylethyl)pyrazine (3) (isopropyl-methoxypyrazine) in grapes and wines. The corresponding trideuterated isopropyl-methoxypyrazine (6) is used in addition to the trideuterated isobutylmethoxypyrazine 5 to provide more accurate quantitative analysis of the isopropyl compound (7, 10,... 

Blom, K.F., Average mass approach to stable isotope dilution mass spectrometry. Mass Spectrom., 22, 530-533 (1987). 

The method described here makes use of stable isotope dilution mass spectrometry (IDMS) for quantitative analysis of niacin. Isotopically labelled versions of both nicotinic acid and niacinamide are commercially available at a reasonable cost. The use of an isotopically labelled internal standard has distinct advantages in quantitative analysis, as it can correct for analyte losses and makes possible high levels of accuracy and precision (Fassett and Paulson 1989). Sample digestion and clean-up is based on a previously published LC-UV method (LaCroix et al. 1999, 2002 LaCroix and Wolf 2001). This chapter expands on a previous report of LC-IDMS analysis of niacin (Goldschmidt and Wolf 2007), with material from that report used with permission of the publisher. 

Stable isotope dilution mass spectrometry (IDMS) can be a definitive analytical method for very accurate concentration determination of pantothenic acid (Cornelis 2003). However, definitive accuracy of the IDMS technique requires full equilibration between endogenous natural amounts of the compound and the isotopically labelled spike, which is usually accomplished by bringing both in the same chemical form in solution. 

Stable isotope dilution mass-spectrometry (MSID) is the most accurate technique for determining lanthanide abundances in geochemical materials.. The superior quality of the method may be attributed principally to the inherent sensitivity of mass-spectrometers, and to the use of the ideal internal standard, namely, an artificially enriched isotope of each element to be determined. The utilization of isotopic internal standards virtually eliminates such potential analytical problems as quantitative recovery and instrument calibration. The sensitivity of the mass spectrometer is such that the lower limit of measurable abundance is usually controlled by the purity of the reagents used in preparing the sample for analysis. 

Bruenner, B.A., Jones, A.D. and German, J.B. (1996) Simultaneous determination of multiple aldehydes in biological tissues and fluids using gas chromatography/stable isotope dilution mass spectrometry. Anal. Biochem. 241, 212-219. 

AJ Clifford, AD Jones, HC Furr. Stable isotope dilution mass spectrometry to assess vitamin A status. Methods Enzymol 189 94-104, 1990. 

Prokai L, Szarka S, Wang X, Prokai-Tatrai K. Capture of the volatile carbonyl metabolites of flecainide on 2,4-dinitrophenylhydrazine cartridge for quantitative stable isotope dilution mass spectrometry coupled with chromatography. J Chromatogr A 2012 1232 281-7. 

Thomas PM, Flanagan VP, Pawlosky RJ. Determination of 5-methyltetrahydrofolic acid and folic acid in citrus juices using stable isotope dilution—mass spectrometry. J Agri Food Chem 2003 51 1293-6. 

Thomas P.M., Flanagan V.P., Pawlosky R.J. Determination of 5-methyltetrahydrofoUc acid and fohc acid in citrus juices using stable isotope dilution-mass spectrometry. Journal of Agricultural and Food Chemistry, 51 1293-1296 (2003). 

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