Spreading depression

A related idea is that peripheral nerves are the source of the problem and then cause the associated vascular changes via release of 5-HT and other inflammatory mediators. The observation that the changes in the vasculature do not follow vascular anatomy has led to a new theory, that of spreading depression . Here, the primary abnormality is... [Pg.457]

Szerb JC. 1991. Glutamate release and spreading depression in the fascia dentata in response to microdialysis with high K role of glia. Brain Res 542(2) 259-265. [Pg.254]

Ayata C, Shimizu-Sasamata M, Lo EH, Noebels JL, Moskowitz MA (2000) Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alphalA subunit of P/Q type calcium channels. Neuroscience 95 639-645. [Pg.244]

Lauritzen M (1994) Pathophysiology of the migraine aura. The spreading depression theory. Brain 117... [Pg.248]

We have seen that sodium enters the cells, but potassium is set free into the extracellular space where it induces irregular depolarizations, particularly in the surroundings of an ischemic focus. Such transient depolarizations travel over the cortex like classical waves of spreading depression of electrical activity (Back et al. 1994b Leao 1944 Nedergaard and Astrup 1986). The number of such peri-infarct depolarizations (PIDs) correlated well with final... [Pg.48]

Alexis NE, Back T, Zhao W, Dietrich WD, Watson BD, Ginsberg MD (1996) Neurobehavioral consequences of induced spreading depression following photothrombotic middle cerebral artery occlusion. Brain Res 706 273-282 Antman EM, Giugliano RP, Gibson CM, McCabe CH, Cous-sement P, Kleiman NS, Vahanian A, Adgey AAJ, Menown... [Pg.67]

Busch E, Gyngell M, Eis M, Hoehn-Berlage M, Hossmann K-A (1996) Potassium-induced cortical spreading depression during focal cerebral ischemia in rats contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging. J Cereb Blood Flow Metab 16 1090-1099... [Pg.68]

Gill R, Andine P, Hillered L, Persson L, Hagberg H (1992) The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischemia in the rat. J Cereb Blood Flow Metab 12 371-379... [Pg.69]

Leao AAP (1944) Spreading depression of activity in the cerebral cortex. J Neurophysiol 7 359-390... [Pg.71]

Marrannes R, Willems R, DePrins E, Wauquier A (1988) Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat. Brain Res 457 226-240... [Pg.71]

Disturbances of proton diffusion are not unique to cerebral ischemia. Reduced diffusion has also been found in various experimental conditions including spreading depression (Busch et al. 1995) and peri-infarct depolarizations (Gyngell et al. 1994 Rother et al. 1996), hypoglycemia (Hasegawa et al. 1996), following cortical application of noxious substances [blockers of the Na+-/K+-ATPase (Benveniste et al. 1992), excitotoxins (Verheul et al. 1994)] and... [Pg.119]

Busch E, Hoehn-Berlage M, Eis M, Gyngell ML, Hossmann KA (1995) Simultaneous recording of EEG, DC potential and diffusion-weighted NMR imaging during potassium induced cortical spreading depression in rats. NMR... [Pg.129]

Largo, C., Ibarz, J. M., Herreras, O. (1997). Effects of the glio-toxin fluorocitrate on spreading depression and glial membrane potential in rat brain in situ. J. Neurophysiol. 78 295-307. [Pg.195]

Lian, X.Y., Stringer, J.L. (2004). Energy failure in astrocytes increases the vulnerability of neurons to spreading depression. Eur. J. Neurosci. 19 2446-54. [Pg.195]

Recent studies have also shown that neuronal depolarization will cause increases in Tj and T. T was shown to increase by 13% while T2 increased by 88% at 1.5 T in a rat model of spreading depression (Stanisz et al., 2002). While... [Pg.754]

Another interesting paper was published by Wolf et al. in 1996 [39] where they used NIR and laser Doppler flowmetry (LDF) to study the effect of systemic nitric oxide synthase (NOS) inhibition on brain oxygenation. The study, performed on rats, demonstrated no effects on brain oxygenation during cortical spreading depression (CSD). [Pg.151]

M. Shibata and J. Bures. Optimum topographical conditions for reverberating cortical spreading depression in rats. J. Neurobiol, 5 107-118, 1974. [Pg.275]

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