Spinal fusion

Deyo RA, Nachemson A, Mirza SK (2004) Spinal-fusion surgery - the case for restraint. 

McIntosh KR et al (2009) hnmunogenicity of allogeneic adipose-derived stem cells in a rat spinal fusion model. Tissue Eng Part A 15(9) 2677-2686... 

Bone Graft Data from the Laboratory of Dr. Ralph Holmes of the University of California, San Diego, on the Spinal Fusion Study by Dr. Glenn O Sullivan, Orthopedic Surgery Staff of Stanford University School of Medicine (10)... 

Figure 20. Photo of spinal fusion in sheep in the Stanford Medical College. X-ray study by Dr. Glenn O Sullivan and Dr. Ralph Holmes.

Histology and new bone growth report received from the Ralph Holmes laboratory at UCSD Medical Center on May 21,1996, concerning Stanford University Medical School study on spinal fusion of sheep. 

Thaller J, Walker M, Kline AJ, Anderson DG. The effect of nonsteroidal anti-inflammatory agents on spinal fusion. Orthopedics. 2005 28 299-303. 

Holm, S. and Nachemson, A. (1982) Nutritional changes in the canine intervertebral disc after spinal fusion. Clin Orthop, 243-258... 

Tumialan LM, Wippold EJ, Morgan RA (2004) Tortuous vertebral artery injury complicating anterior cervical spinal fusion in a symptomatic rheumatoid cervical spine. Spine 29 E323-E348. 

There have been another two studies of the analgesic effect of intrathecal morphine in children (34,35). In a prospective, double-blind study, 30 children (aged 9-19 years) scheduled for spinal fusion were randomly allocated to a single dose of saline or intrathecal morphine 2 or 5 pg/kg after surgery, a PCA device provided access to additional intravenous morphine (34). The doses of 2 and 5 pg/kg had similar analgesic effectiveness and adverse effects profiles (nausea, vomiting, pruritus). There were no episodes of severe respiratory depression. Low-dose intrathecal morphine supplemented with PCA morphine provides better analgesia than PCA morphine alone. 

Gall O, Aubineau JV, Berniere J, Desjeux L, Murat I. Analgesic effect of low-dose intrathecal morphine after spinal fusion in children. Anesthesiology 2001 94(3) 447-52. 

Dimar JR 2nd, Ante WA, Zhang YP, Glassman SD. The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the rat. Spine 1996 21(16) 1870-6. 

KM is a 20-year-old woman with a history of epilepsy and scoliosis. Her seizures have been controlled on a maintenance dosage of divalproex sodium. She is scheduled to undergo a spinal fusion, and will not be taking anything by mouth (NPO) for several days. Which factor should be taken into consideration for her postsurgical care ... 

Glassman, S.D., Dimarm, J.R., Carreon, L.Y., Campbell, M.J., Puno, R.M., Johnson, J.R. 2005. Initial fusion rates with recombinant human bone morphogenetic protein-2/compression resistant matrix and a hydroxyapatite and tricalcium phosphate/collagen carrier in posterolateral spinal fusion. Spine 30(15), 1694-1698. 

J. C. Fernyhough, J. J. Schimandle, M. C. Weigel, C. C. Edwards, and A. M. Levine, Chronic Donor Site Pain Compiicating Bone Graft ffarvesting from the Posterior lUac Crest for Spinal Fusion, Spine, 17, 1474-80 (1992). 

Fernyhough JC, Schimandle JJ, Weigel MC, Edwards CC, Levine AM. Chronic donor site pain complicating bone graft harvesting from the posterior iliac crest for spinal fusion. Spine 1992 17 1474-80. 

Williams BJ, Smith JS, Fu KM, Hamilton DK, Polly DW, Jr., Ames CP, et al. Does bone morphogenetic protein increase the incidence of perioperative complications in spinal fusion A comparison of 55,862 cases of spinal fusion with and without bone morphogenetic protein. Spine. 2011 36 1685-91. 

Kostuik J.P. 1998. Alternatives to spinal fusion. Orthop Clin North Ant 29 701-715. 

Tilkeridis, K., Touzopoulos, R, Ververidis, A., Christodoulou, S., Kazakos, K., Drosos, G.I., 2014. Use of demineralized bone matrix in spinal fusion. World J. Orthop. 5, 30-37. 

---