Sphingolipids metabolizing enzymes

Delgado A, Casas J, Llebaria A, Abad JL, Fabrias G. Inhibitors of sphingolipid metabolism enzymes. Biochim. Biophys. Acta 2006 1758 1957-1977. 

Figure 8 Outline of the sphingolipid biosynthetic pathway. Natural and synthetic inhibitors of sphingolipid-metabolizing enzymes are shown adjacent to the inverted T bars.

Chatteijee, D., Mukheijee, S., Smith, M.G., and Das, S.K. (2004). Role of sphinomyelinase in the environmental toxin induced apoptosis of pulmonary cells. In In Lipids Sphingolipid Metabolizing Enzymes, eds. Dipak, Haidar, and Salil K Das, Research Signpost, pp. 117-139, Trivandum, Kerala, India. 

Kok, J.W. and Sietsma, H. Sphingolipid metabolism enzymes as targets for anticancer therapy. Curr Drug Targets, 5, 2004, 375-382. 

Sphingolipid Metabolizing Enzymes as Novel Therapeutic Targets... 

Delgado, A., Casas, J., Llebaria, A., Abad, J.L., and Fabrias, G., Inhibitors of sphingolipid metabolism enzymes, Biochim Biophys Acta, 1758 (2006) 1957-1977. 

The recent cloning and sequencing of many sphingolipid metabolic enzymes has allowed the genetic manipulation of their protein levels in cells by overexpression and knockout. 

The emerging roles of ceramide in growth suppression, apoptosis and stress response have focused attention on the role of ceramide, sphingolipid-metabolizing enzymes, and ceramide targets in the pathology and treatment of disease (Table 3). 

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