Yeast, sphingolipids

Sims, K.J., Spassieva, S.D., Voit, E.O., and Obeid, L.M., 2004, Yeast sphingolipid metabolism Clues and connections. Biochem. Cell Biol. 82 45-61. 

Cerantola, V., Vionnet, C., Aebischer, O.F., Jenny, T., Knudsen, J., and Conzelmann, A. Yeast sphingolipids do not need to contain very long chain fatty acids. Biochem J, 401, 2007, 205-216. 

Jenkins, GM, Richards, A, Wahl, T, Mao, C, Obeid, L and Hannun, Y (1997) Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J Biol Chem, 212, 32566-32572. 

Sims, KJ, Spassieva, SD, Voit, EO and Obeid, LM (2004) Yeast sphingolipid metabolism clues and connections. Biochem Cell Biol, 82(1), 45-61. 

Ejsing, C.S., Moehring, T., Bahr, U., Duchoslav, E., Karas, M., Simons, K. and Shevchenko, A. (2006) Collision-induced dissociation pathways of yeast sphingolipids and their molecular profiling in total lipid extracts A study by quadrupole TOP and linear ion trap-orbitrap mass spectrometry. J. Mass Spectrom. 41, 372-389. 

Yeast sphingolipids contain inositol rather than choline, as is the case for sphingomyelin in mammalian cells [34],... 

Schneiter, R. (1999) Brave little yeast, please guide us to Thebes sphingolipid function in S. cerevisiae. BioEssays 21, 1004 1010. 

Watanabe, R., Funato, K., Venkataraman, K., Futerman, A. H., and Riezman, H. (2002). Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. J. Biol. Chem. 277(51), 49538—49544. 

Teles JH, Breuer K, Enders D, Gielen H (1999) One pot synthesis of 3,4-disubstituted l-alkyl-4H-l,2,4-triazol-l-ium salts. Synth Commun 29 1-9 Thorpe SR, Sweeley C (1967) Chemistry and metabolism of sphingolipids. On the biosynthesis of phytosphingosine by yeast. Biochemistry 6 887... 

A protein that would be a logical interaction partner for SPT is 3-ketosphinganine reductase, which catalyzes the next step of the sphingolipid biosynthetic pathway. The gene for this reductase has been identified in yeast (T. Beeler, 1998) and in mammals (FVTl) (A. Kihara, 2004), and the sequence has coil-coil motifs that might interact with a similar motifs on SPT. 

Concomitant to IPC formation, Ipcl also produces diacylglycerol (DAG) and consumes phytoceramide. ITie importance of Ipcl therefore may be due not only to the formation of IPC itself, one of the more abundant sphingolipids in the membranes, but also to the regulation of phytoceramide, implicated in growth arrest and yeast stress responses [85, 86], and DAG, a well-established mitogen and activator of protein kinase C (PKC). 

Features Natural key building block of sphingolipids present in the epidermis inhibits growth of gram-positive and -ngeative bacteria, yeast, and fungi... 

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