Post-genomic approaches

Dunn, T.M., Lynch, D.V, Michaelson, L.V, and Napier, J.A., 2004, A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana. Ann. Bot. (Lond.) 93 483 197. 

Tang, J. et al., Integrating post-genomic approaches as a strategy to advance our understanding of health and disease, Genome Med., 30, 35, 2009. 

Winkel-Shirley, B., A mutational approach to dissection of fiavonoid biosynthesis in Arabidopsis, in Phytochemistry in the Genomics and Post-Genomics Eras, Romeo, J.T. and Dixon, R.A., Eds., Pergamon, New York, 2002, 95. 

Betz, S.F., S.M. Baxter, and J.S. Fetrowm. 2002. Function first A powerful approach to post genomic drug discovery. Drug Discov Today 7 8765. 

Up to now, chemogenomics has been applied to a diversity of approaches that use chemical compounds to interrogate biological systems [2-4], but since some of these approaches have only peripheral relevance to drug discovery, we felt it worthwhile to focus on those aspects that address key issues posed by the sharp decrease in pharmaceutical productivity that has occurred in the post-genome era. 

The protocol uses alignment of secondary-structure elements and looks for identical three-dimensional orientation as depicted in Fig. 56. The best scoring proteins are selected in this approach. It is no risk to assume that this type of approach will be used for structure elucidation in the post genomic era where minimal effort will be spent on proteins with homologous structures. 

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