Specific Organ Manifestation

Pulmonary involvement is noted in 55% to 80% of patients with WG (1,3,5,8,10). The spectmm of pulmonary manifestations includes asymptomatic 

Other rare urologic complications of WG include renal artery aneurysms (73,74), renal masses (75,76), necrotizing vasculitis involving the ureters (74), ureteral stenosis (72,77), penile necrosis (73) or ulcers (77), acute urinary retention (72), bladder pseudotumor (77), and involvement of the prostate (3,78). 

Peripheral neuropathy, due to involvement of the vasa vasorum, is noted in 30% to 43% of patients during the course of the disease (3,5,79-81,91). Most common manifestations include mononeuritis multiplex or polyneuritis (3,5,79). Peripheral neuropathy is more common in males, older age, greater extent of disease, and higher titers of ANCA (79). In some patients, biopsy of the sural nerve or other affected nerves may substantiate the diagnosis. Both peripheral and CNS manifestations may be associated with irreversible damage, persisting even after the acute inflammation is adequately controlled. 

Involvement of medium-sized or large arteries is rare in WG. However, case reports of WG with aneurysms or macroscopic inflammatory lesions involving 

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Target organ A specific organ where the toxic effect of a substance is manifested. 

Metzler M, McLachlan JA. Diethylstilbestrol metabolic transformation in relation to organ specific tumor manifestation. Arch Toxicol 1979 (suppl 2) 275-280. 

The reason of such peculiar and specific spectroscopic manifestations is that complex Fermi resonance phenomena occur in molecules containing polymethylene chains. We are concerned in this chapter on the Fenni resonances associated with the vibrations of polymethylene systems in the trans or gauche states, considered either as isolated entities and/or when they are organized in ordered and/or disordered supermolecular structures. Let us remember that Fermi resonance derives... 

Autoimmune diseases may inflict on each organ or cell. Manifestations range from affecting a single cell type and its specific function (such as the (3-cell of the islands in the pancreas) to systemic diseases which have a detrimental effect on an entire organ system (e.g. the vasculature) of even many different organs. Table 1 summarizes some clinically important diseases. 

Fischer, brilliant results were achieved, and in succession the a-amylases of pig pancreas, of Bacillus subtilis, of human saliva, of human pancreas, and of Aspergillus oryzae, and the /3-amylase of malt, were successfully crystallized. Important biological deductions were gained from this study whereas the amylases of human pancreas and saliva cannot be distinguished from one another, amylases from pig pancreas and from human pancreas are different. These differences are manifested in molecular weight, crystalline forms, electrophoretic mobility, and influence of the pH on the activity however, all the amylases have the same specific biochemical action. The identity of the enzymes seems to be dependent on the species and not on the organ. Interest in biologically active proteins led Meyer to a study of the protein hormones, a field in which he was very active at the time of his death. 

Hence, DHS will manifest the greatest solubility enhancement for those pollutants which are the least soluble in water or the most attracted to the solid phase. Organic pollutants, which are soluble in water, are less likely to be sorbed onto the solid or colloidal phase in the absence of specific bonding interactions. 

The book is organized in nine chapters and eleven appendices. Chapters 1 and 2 introduce the fundamental concepts and definitions. Chapters 3 to 7 treat binding systems of increasing complexity. The central chapter is Chapter 4, where all possible sources of cooperativity in binding systems are discussed. Chapter 8 deals with regulatory enzymes. Although the phenomenon of cooperativity here is manifested in the kinetics of enzymatic reactions, one can translate the description of the phenomenon into equilibrium terms. Chapter 9 deals with some aspects of solvation effects on cooperativity. Here, we only outline the methods one should use to study solvation effects for any specific system. 

There are three big groups with clear, specific actions to treat three aspects of the syndrome and they are organized in a very balanced way. They treat the cause and the manifestations at the same time they focus on stopping the pathological development of Liver-Yang and Liver-wind but do not ignore the proper movement of the Qi, the condition of the Stomach and the Liver. 

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